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2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop

Pharmacological Research(2021)10.1016/j.phrs.2021.105685Source: DataRank Database

2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop is a research paper published in Pharmacological Research (2021). On theSindex it has a DataRank of 0.425. It has been cited 16 times.

N/A

0.425DataRank · unranked

Scored on demand from live citation data

Open Access16 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (14 grants)Impact (FWCI 0.94)OA: hybridTopics (65)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.425

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (15)

Jiaping Ni ORCID,Ying Li ORCID,Ming‐Ying Lu ORCID,Yuchen Yao ORCID,Haixin Guo

Live enrichment

PubMed:34022398 OpenAlex:https://openalex.org/W3164338743

Postdoctoral Science Foundation of Jiangsu Province

Grant: 1701054A

National Institutes of Health

Grant: Z01-ES-101684

National Natural Science Foundation of China

Grant: 81672752

National Natural Science Foundation of China

Grant: 81703561

National Natural Science Foundation of China

Grant: 82003788

National Natural Science Foundation of China

Grant: 82073280

Ministry of Science and Technology of the People's Republic of China

Grant: 2018ZX09201017-006

Natural Science Foundation of Jiangsu Province

Grant: BK20180560

Natural Science Foundation of Jiangsu Province

Grant: BK20180575

Natural Science Foundation of Jiangsu Province

Grant: BK20190801

Intramural NIH HHS

Grant: Z01 ES101684

Double First Class University Plan

China Pharmaceutical University

State Key Laboratory of Natural Medicines

FWCI

0.94

Citation Percentile

0.7%

Citation Trend

2021

2022

2023

2024

2025

hybridLicense: cc-by

journalhttps://doi.org/10.1016/j.phrs.2021.105685

publisherhttps://doi.org/10.1016/j.phrs.2021.105685

publisherhttps://api.elsevier.com/content/article/PII:S1043661821002693?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1043661821002693?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34022398

Fields of Study

Cancer, Hypoxia, and MetabolismHepatocellular Carcinoma Treatment and PrognosisCancer, Lipids, and Metabolism2-MethoxyestradiolAnimalsAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsBasic Helix-Loop-Helix ProteinsCarcinoma, HepatocellularCell Line, TumorDNA-Binding ProteinsDrug SynergismErbB ReceptorsErlotinib HydrochlorideHumansHypoxia-Inducible Factor 1, alpha SubunitLiver NeoplasmsMaleMice, Inbred BALB CMice, Inbred NODMice, NudeNeoplasm TransplantationRNA-Binding ProteinsSignal TransductionTranscription FactorsMiceEndothelial PAS Domain-Containing Protein 1

MeSH Terms

Erlotinib Hydrochloride2-MethoxyestradiolEndothelial PAS Domain-Containing Protein 1AnimalsAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsDNA-Binding ProteinsDrug SynergismCarcinoma, HepatocellularHumansLiver NeoplasmsMaleMice, Inbred BALB CMice, NudeNeoplasm TransplantationTranscription FactorsSignal TransductionRNA-Binding ProteinsMice, Inbred NODCell Line, TumorMiceBasic Helix-Loop-Helix Transcription FactorsBasic Helix-Loop-Helix ProteinsHypoxia-Inducible Factor 1, alpha SubunitErbB Receptors

Keywords

ErlotinibHepatocellular carcinomaMedicineCancer researchPharmacologyErlotinib HydrochlorideEpidermal growth factor receptorEGFR inhibitorsCancerInternal medicine2-MethoxyestradiolHypoxia-inducible FactorsPleomorphic Adenoma Gene Like-2

Sustainable Development Goals

SDG 0: Good health and well-being