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Targeting adenosine 2A receptor signaling suppresses vascular calcification by restraining smooth muscle osteogenic differentiation

Pharmacological Research(2025)10.1016/j.phrs.2025.108012Source: DataRank Database

Targeting adenosine 2A receptor signaling suppresses vascular calcification by restraining smooth muscle osteogenic differentiation is a research paper published in Pharmacological Research (2025). On theSindex it has a DataRank of 0.104. It has been cited 1 time, with 1 citing works in its 1-hop citation network.

N/A

0.104DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access1 citations · 1 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE159833

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (16 grants)Impact (FWCI 0.64)OA: goldTopics (49)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.104

From this paper's citation signal

Citation Network Contribution

From 0 citing papers with measurable signal

This paper's DataRank is currently driven only by its base citation score. None of the citing papers had measurable citation signal.

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Authors (18)

Dingwei Zhao,Qian Ma ORCID,Sujin Lee ORCID,Kangsan Roh ORCID,Yongfeng Cai

Live enrichment

PubMed:41201506 OpenAlex:https://openalex.org/W4415546169

National Institutes of Health

Grant: R01EY033369

National Institutes of Health

Grant: R01HL142809

National Institutes of Health

Grant: R01HL162928

National Institutes of Health

Grant: R01EY030500

National Institutes of Health

Grant: R01EY033737

China Postdoctoral Science Foundation

Grant: 2020M670051

Chinese Academy of Sciences Shenzhen-Hong Kong Brain Science Innovation Institute

Grant: 2024SHIBS0004

Basic and Applied Basic Research Foundation of Guangdong Province

Grant: 2023A1515010816

American Heart Association Inc

Grant: 23POST1026238

American Heart Association Inc

Grant: 22TPA968801

National Natural Science Foundation of China

Grant: 82070461

Shenzhen Science and Technology Innovation Program

Grant: RCBS20200714114820147

NHLBI NIH HHS

Grant: R01 HL148239

NHLBI NIH HHS

Grant: R01 HL164577

NIDDK NIH HHS

Grant: U01 DK142283

Science, Technology and Innovation Commission of Shenzhen Municipality

FWCI

0.64

Citation Percentile

0.7%

Citation Trend

2026

goldLicense: cc-by

journalhttps://doi.org/10.1016/j.phrs.2025.108012

publisherhttps://doi.org/10.1016/j.phrs.2025.108012

publisherhttps://api.elsevier.com/content/article/PII:S1043661825004372?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1043661825004372?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41201506

Fields of Study

Parathyroid Disorders and TreatmentsCoagulation, Bradykinin, Polyphosphates, and AngioedemaAdenosine and Purinergic SignalingAnimalsVascular CalcificationReceptor, Adenosine A2AOsteogenesisHumansMuscle, Smooth, VascularSignal TransductionCell DifferentiationMaleMice, Inbred C57BLMyocytes, Smooth MuscleMiceCells, CulturedCore Binding Factor Alpha 1 SubunitAdenosine A2 Receptor AntagonistsMice, KnockoutCyclic AMP Response Element-Binding Protein

MeSH Terms

AnimalsCell DifferentiationCells, CulturedHumansMaleMice, Inbred C57BLMuscle, Smooth, VascularOsteogenesisSignal TransductionCyclic AMP Response Element-Binding ProteinMice, KnockoutMyocytes, Smooth MuscleReceptor, Adenosine A2ACore Binding Factor Alpha 1 SubunitMiceAdenosine A2 Receptor AntagonistsVascular Calcification

Keywords

CalcificationVascular smooth muscleRUNX2AdenosineEx vivoIn vivoDownregulation and upregulationAdenosine receptorOsteogenic differentiationVascular CalcificationCkdAdora2a