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Redox regulation of lung endothelial PERK, unfolded protein response (UPR) and proliferation via NOX1: Targeted inhibition as a potential therapy for PAH

Redox Biology(2025)10.1016/j.redox.2025.103554Source: DataRank Database

Redox regulation of lung endothelial PERK, unfolded protein response (UPR) and proliferation via NOX1: Targeted inhibition as a potential therapy for PAH is a research paper published in Redox Biology (2025). On theSindex it has a DataRank of 0.255. It has been cited 4 times, with 4 citing works in its 1-hop citation network.

N/A

0.255DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access4 citations · 4 citing works in its network

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Linked data & code

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Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE291410

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (8 grants)Impact (FWCI 3.58)OA: goldTopics (51)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 95%Citation Network 5%

Base Score Contribution

0.241

From this paper's citation signal

Citation Network Contribution

0.0140

From 2 citing papers with measurable signal

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Top 4 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 4 citers.

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Cell Proliferation20250 citations272 referencesContributes 0.000
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20260 citations169 referencesContributes 0.000

Authors (11)

Alex Kufner,Christopher M. Dustin ORCID,Imad Al Ghouleh ORCID,Shuai Yuan ORCID,Adam C. Straub ORCID

Live enrichment

PubMed:40154102 PMC:PMC11986987 OpenAlex:https://openalex.org/W4407740231

NIH Library

Grant: P01 HL103455

American Heart Association Inc

Grant: 18TPA34170069

NHLBI NIH HHS

Grant: R01 HL142248

NHLBI NIH HHS

Grant: R35 HL161177

NIGMS NIH HHS

Grant: T32 GM133332

NHLBI NIH HHS

Grant: R01 HL146465

NIH NRSA

Grant: F31 1HL167563

NHLBI NIH HHS

Grant: R01 HL166425

FWCI

3.58

Citation Percentile

0.9%

Citation Trend

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.redox.2025.103554

publisherhttps://doi.org/10.1016/j.redox.2025.103554

publisherhttps://api.elsevier.com/content/article/PII:S2213231725000679?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2213231725000679?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40154102

Fields of Study

Pulmonary Hypertension Research and TreatmentsEndoplasmic Reticulum Stress and DiseaseCoenzyme Q10 studies and effectsUnfolded Protein ResponseAnimalsMiceCell ProliferationHumansNADPH Oxidase 1eIF-2 KinaseEndothelial CellsLungOxidation-ReductionReactive Oxygen SpeciesPulmonary Arterial HypertensionMaleDisease Models, Animal

MeSH Terms

NADPH Oxidase 1Pulmonary Arterial HypertensionAnimalsDisease Models, AnimalHumansLungMaleOxidation-ReductionReactive Oxygen SpecieseIF-2 KinaseEndothelial CellsCell ProliferationMiceUnfolded Protein Response

Keywords

Unfolded protein responseCancer researchCell growthTargeted therapyNOX1Oxidative stressChemistryApoptosisCell biologyBiologyMedicineBiochemistryInternal medicineNADPH oxidaseCancerHypoxiaPulmonary Arterial HypertensionNadph OxidasesNox InhibitorsNoxa1ds

Sustainable Development Goals

SDG 0: Zero hunger

Redox regulation of lung endothelial PERK, unfolded protein response (UPR) and proliferation via NOX1: Targeted inhibition as a potential therapy for PAH

FAIR Checklist

DataRank Breakdown

Top 4 citers driving the network score

Authors (11)

Funding (8 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)