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The absence of Peroxiredoxin-1 in human pancreatic ductal adenocarcinoma (PDAC) markedly reduces cell survival and tumor growth when coupled with the inhibition of Ref-1 redox signaling

Redox Biology(2025)10.1016/j.redox.2025.103848Source: DataRank Database

The absence of Peroxiredoxin-1 in human pancreatic ductal adenocarcinoma (PDAC) markedly reduces cell survival and tumor growth when coupled with the inhibition of Ref-1 redox signaling is a research paper published in Redox Biology (2025). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Open Access3 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (15 grants)Impact (FWCI 1.92)OA: goldTopics (53)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Randall Wireman,Jacqueline Peil,Dana K. Mitchell ORCID,Elizabeth A. Sierra Potchanant ORCID,Ratan Kumar ORCID

Live enrichment

PubMed:40902319 PMC:PMC12445586 OpenAlex:https://openalex.org/W4413854318

NCI NIH HHS

Grant: R01 CA167291

National Institutes of Health National Cancer Institute

Grant: HT94252410689

National Institutes of Health National Cancer Institute

Grant: R01CA282478

NCI NIH HHS

Grant: P30 CA082709

National Institutes of Health National Cancer Institute

Grant: R01CA254110

NIGMS NIH HHS

Grant: R35 GM146888

National Institutes of Health

Grant: 3R01CA282478-01S1

Metabolic flux analysis and PDX models to understand therapeutic vulnerabilities following inhibition of Ref-1 redox signaling in pancreatic cancer

National Institutes of Health

Grant: 1R01CA254110-01A1

Investigation of novel signaling protein in 3D and in vivo PDAC models using second generation Ref-1 inhibitors

National Institutes of Health

Grant: 7U01CA274304-03

Reprogramming PDAC Stroma by Targeting Coagulation in the Tumor Microenvironment

National Institutes of Health

Grant: 3P30CA082709-16S3

Indiana University Melvin and Bren Simon Cancer Center Support Grant

National Institutes of Health

Colorectal Cancer Alliance

Riley Children's Foundation

US Department of Defense

Plastic Surgery Research Council

FWCI

1.92

Citation Percentile

0.9%

Citation Trend

2025

2026

goldLicense: cc-by-nc

journalhttps://doi.org/10.1016/j.redox.2025.103848

publisherhttps://doi.org/10.1016/j.redox.2025.103848

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40902319

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12445586

repositoryhttps://doaj.org/article/d996e68d842f432f8d9b9d229b1059f5

Fields of Study

Redox biology and oxidative stressGlutathione Transferases and PolymorphismsEnzyme function and inhibition03 medical and health sciences0302 clinical medicine

MeSH Terms

AnimalsCell SurvivalHumansOxidation-ReductionPancreatic NeoplasmsSignal TransductionGene Expression Regulation, NeoplasticApoptosisCarcinoma, Pancreatic DuctalXenograft Model Antitumor AssaysDNA-(Apurinic or Apyrimidinic Site) LyaseCell Line, TumorCell ProliferationMicePeroxiredoxins

Keywords

Pancreatic ductal adenocarcinomaCancer researchCell growthBiologyAdenocarcinomaPeroxiredoxinCell biologyPancreatic cancerChemistryInternal medicineMedicineCancerBiochemistryNF-κBHIF-1αTumor MicroenvironmentRedox Factor-1Cell SurvivalApoptosisPeroxiredoxinsXenograft Model Antitumor AssaysPancreatic NeoplasmsGene Expression Regulation, NeoplasticMiceCell Line, TumorDNA-(Apurinic or Apyrimidinic Site) LyaseHumansAnimalsOxidation-ReductionResearch PaperCarcinoma, Pancreatic DuctalSignal TransductionCell Proliferation

Sustainable Development Goals

SDG 0: Zero hunger

The absence of Peroxiredoxin-1 in human pancreatic ductal adenocarcinoma (PDAC) markedly reduces cell survival and tumor growth when coupled with the inhibition of Ref-1 redox signaling

FAIR Checklist

Authors (12)

Funding (15 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)