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Roflumilast, a phosphodiesterase-4 (PDE4) inhibitor, induces respiratory frequency plasticity that is resistant to inflammation in neonatal rat in vitro preparations

Respiratory Physiology & Neurobiology(2025)10.1016/j.resp.2025.104435Source: DataRank Database

Roflumilast, a phosphodiesterase-4 (PDE4) inhibitor, induces respiratory frequency plasticity that is resistant to inflammation in neonatal rat in vitro preparations is a research paper published in Respiratory Physiology & Neurobiology (2025). On theSindex it has a DataRank of 0.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (2 grants)Impact (FWCI 0.00)OA: greenTopics (49)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Jacob P Rastas,Pujal S. Desai,Tracy L. Baker ORCID,Jyoti J. Watters ORCID,Stephen M. Johnson ORCID

Live enrichment

PubMed:40228690 OpenAlex:https://openalex.org/W4409483470

National Institutes of Health

Grant: R01 HL142752

National Institutes of Health

FWCI

0.00

Citation Percentile

0.1%

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12068955/

publisherhttps://api.elsevier.com/content/article/PII:S1569904825000461?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1569904825000461?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.resp.2025.104435

Fields of Study

Neonatal Respiratory Health ResearchNeuroscience of respiration and sleepAsthma and respiratory diseasesAnimalsAminopyridinesCyclopropanesPhosphodiesterase 4 InhibitorsBenzamidesAnimals, NewbornLipopolysaccharidesRatsInflammationNeuronal PlasticitySpinal CordRats, Sprague-DawleyDose-Response Relationship, DrugIn Vitro Techniques

MeSH Terms

AminopyridinesAnimalsAnimals, NewbornBenzamidesCyclopropanesDose-Response Relationship, DrugInflammationLipopolysaccharidesNeuronal PlasticitySpinal CordRats, Sprague-DawleyRatsPhosphodiesterase 4 InhibitorsIn Vitro Techniques

Keywords

RoflumilastPhosphodiesteraseInflammationRespiratory systemIn vitroPharmacologyPhosphodiesterase inhibitorMedicineChemistryImmunologyInternal medicineEnzymeBiochemistrycAMPPKAneonatal ratEpacRespiratory Motor Control