Pilot corpus: NIH-funded biomedical datasets. Any DOI can be scored on demand — network effects sharpen as coverage grows.

A novel fluorogenic reporter substrate for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCγ2): Application to high-throughput screening for activators to treat Alzheimer's disease

SLAS DISCOVERY(2023)10.1016/j.slasd.2023.03.003Source: DataRank Database

A novel fluorogenic reporter substrate for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCγ2): Application to high-throughput screening for activators to treat Alzheimer's disease is a research paper published in SLAS DISCOVERY (2023). On theSindex it has a DataRank of 0. It has been cited 3 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access3 citations

Download PDF

Cite:

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 0.28)OA: goldTopics (41)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

FAIR checklist signals are shown for context only and do not affect DataRank scoring.

Run a calibrated FAIR evaluation for this paper →

We only score data papers we can read in full — never from an abstract alone.

Authors (10)

Tadanobu Utsuki,Daniel E. Beck,Emma K. Lendy ORCID,Kuai-lin Sun,Yinghui Liu ORCID

Live enrichment

PubMed:36933698 PMC:PMC10251139 OpenAlex:https://openalex.org/W4327560432

National Institute on Aging

Grant: 1U54AG065181

NIA NIH HHS

Grant: U54 AG065181

NCI NIH HHS

Grant: R01 CA069202

National Institutes of Health

Grant: 5U54AG065181-03

IUSM Alzheimer's Disease Drug Discovery Center

National Institutes of Health

FWCI

0.28

Citation Percentile

0.5%

Citation Trend

2024

2025

goldLicense: cc-by-nc-nd

journalhttp://slas-discovery.org/article/S2472555223000242/pdf

publisherhttp://slas-discovery.org/article/S2472555223000242/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2472555223000242?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2472555223000242?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.slasd.2023.03.003

Fields of Study

Phosphodiesterase function and regulationCholinesterase and Neurodegenerative DiseasesSynthesis and Catalytic ReactionsHumansAlzheimer DiseaseFluorescent DyesPhospholipase C gammaHigh-Throughput Screening AssaysCoumarins

MeSH Terms

Alzheimer DiseaseCoumarinsFluorescent DyesHumansPhospholipase C gammaHigh-Throughput Screening Assays

Keywords

High-throughput screeningChemistryPhosphodiesteraseSubstrate (aquarium)PharmacologyBiochemistryEnzymeCombinatorial chemistryBiologyPhospholipase CAlzheimer's diseaseHigh throughput screeningPlcg2Turn-on FluorophoreC8cf3-coumarinMedicine (General)Phospholipase C gammaArticleHigh-Throughput Screening AssaysR5-920Alzheimer DiseaseCoumarinsHumansTP248.13-248.65BiotechnologyFluorescent Dyes

Sustainable Development Goals

SDG 0: Good health and well-being