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Discovery and validation of small molecule stabilizers of mutant triose phosphate isomerase (TPI) as potential lead candidates for TPI deficiency

SLAS DISCOVERY(2025)10.1016/j.slasd.2025.100278Source: DataRank Database

Discovery and validation of small molecule stabilizers of mutant triose phosphate isomerase (TPI) as potential lead candidates for TPI deficiency is a research paper published in SLAS DISCOVERY (2025). On theSindex it has a DataRank of 0.104. It has been cited 1 time.

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0.104DataRank · unranked

Scored on demand from live citation data

Open Access1 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 0.59)OA: goldTopics (40)IDs (PubMed, PMC, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.104

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (16)

Presley Roberts,Samantha L. Eicher ORCID,Marta Wołosowicz ORCID,Priyal Patel ORCID,Joseph R. Figura

Live enrichment

PubMed:40967261 PMC:PMC12707346 OpenAlex:https://openalex.org/W4414257903

National Institutes of Health

Grant: R01 HD105311

National Institutes of Health

Grant: R01 HD104346

National Institutes of Health

Grant: P30 CA047904

National Institutes of Health

Grant: S10 OD028450

University of Pittsburgh

Grant: S10 OD023402

University of Pittsburgh

Grant: S10 OD032141

FWCI

0.59

Citation Percentile

0.7%

Citation Trend

2025

goldLicense: cc-by

journalhttps://www.slas-discovery.org/article/S2472-5552(25)00071-1/pdf

publisherhttps://www.slas-discovery.org/article/S2472-5552(25)00071-1/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2472555225000711?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2472555225000711?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.slasd.2025.100278

Fields of Study

Erythrocyte Function and PathophysiologyCancer, Hypoxia, and MetabolismNeonatal Health and BiochemistryTriose-Phosphate IsomeraseHumansAnimalsMiceDrug DiscoverySmall Molecule LibrariesAnemia, Hemolytic, Congenital NonspherocyticHigh-Throughput Screening AssaysMutationDisease Models, AnimalCarbohydrate Metabolism, Inborn ErrorsTriosephosphate Isomerase Deficiency

MeSH Terms

Anemia, Hemolytic, Congenital NonspherocyticAnimalsCarbohydrate Metabolism, Inborn ErrorsDisease Models, AnimalHumansMutationTriose-Phosphate IsomeraseMiceSmall Molecule LibrariesDrug DiscoveryHigh-Throughput Screening Assays

Keywords

Triosephosphate isomeraseSmall moleculeMutantPhenotypeLead compoundMutationDrug discoveryChemical geneticsPhenotypic screeningTriose phosphate isomeraseMetabolic DiseaseHigh-content ScreeningTpi DeficiencyEarly Childhood Disease