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ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response

Cell stem cell(2021)10.1016/j.stem.2020.12.018Source: DataRank Database

ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response is a research paper published in Cell stem cell (2021). On theSindex it has a DataRank of 0. It has been cited 228 times.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (14 grants)Impact (FWCI 20.75)OA: bronzeTopics (104)Linked Datasets (12)DataCite Reuse (12)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

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Context only (not used in score)

Findable (2/2)

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Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (10)

Mingzi Zhang ORCID,Gustavo Garcia ORCID,Erpo Tian,Qi Cui ORCID,Xianwei Chen ORCID

Live enrichment

PubMed:33450186 PMC:PMC7832490 OpenAlex:https://openalex.org/W3117551966

National Institutes of Health

Grant: R01 AG056305

National Institutes of Health

Grant: RF1 AG061794

National Institutes of Health

Grant: R56 AG061171

National Cancer Institute

Grant: P30CA33572

National Institute of Allergy and Infectious Diseases

Grant: R21AI129471

California Institute for Regenerative Medicine

Grant: TRAN1-08525

California Institute for Regenerative Medicine

Grant: DISC2-12172

NCI NIH HHS

Grant: P30 CA033572

National Institutes of Health

Grant: 1R56AG061171-01

Uncovering the molecular and cellular mechanisms underlying AD using CRISPR/Cas9-edited isogenic neural cells

National Institutes of Health

Grant: 5R01AG056305-05

Modeling Alzheimer’s disease using directly reprogrammed isogenic neural cells

National Institutes of Health

Grant: 5P30CA033572-27

Developmental Funds

National Institutes of Health

Grant: 1R21AI129471-01

Identify ZIKV host factors with an improved CRISPR-based genome-wide knockout screen

National Institutes of Health

Grant: 1RF1AG061794-01

ApoE2 in Alzheimer's disease: the neuroprotective effects and mechanisms

National Institute on Aging

FWCI

20.75

Citation Percentile

1.0%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

bronzeLicense: Elsevier Non-Commercial

journalhttp://www.cell.com/article/S1934590920306020/pdf

publisherhttp://www.cell.com/article/S1934590920306020/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1934590920306020?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1934590920306020?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.stem.2020.12.018

Fields of Study

Long-Term Effects of COVID-19SARS-CoV-2 and COVID-19 ResearchNeuroinflammation and Neurodegeneration Mechanisms0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

COVID-19SARS-CoV-2Adenosine MonophosphateAlanineAnimalsAntiviral AgentsApolipoproteins EAstrocytesBrainCell DifferentiationChlorocebus aethiopsHumansNerve DegenerationNeuronsOrganoidsSynapsesVero CellsNeuritesTropismProtein IsoformsInduced Pluripotent Stem Cells

Keywords

BiologyAstrocyteInduced pluripotent stem cellCoronavirus disease 2019 (COVID-19)OrganoidSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Apolipoprotein EHuman Induced Pluripotent Stem CellsNeuronVirology2019-20 coronavirus outbreakDiseaseNeuroscienceImmunologyCell biologyPathologyInfectious disease (medical specialty)GeneGeneticsCentral nervous systemMedicineNeuronsAlzheimer's diseaseapoEAstrocytesInduced Pluripotent Stem CellsIpscsBrain OrganoidsNeuron-astrocyte Co-cultureRemdesivirCovid-19Sars-cov-2 NeurotropismAgingBiomedical and clinical sciencesCoronavirusesNeurodegenerativeMedical and Health SciencesCoronaviruses Therapeutics and InterventionsChlorocebus aethiops2.1 Biological and endogenous factorsProtein IsoformsAlanineStem Cell Research - Induced Pluripotent Stem Cell - HumanBrainCell DifferentiationBiological SciencesCoronaviruses Disparities and At-Risk PopulationsOrganoidsInfectious DiseasesNeurologicalMolecular Medicine570Clinical Sciences610Antiviral AgentsTropismShort ArticleApolipoproteins EAcquired Cognitive ImpairmentNeuritesAnimalsHumansVero CellsStem Cell Research - Induced Pluripotent Stem CellSARS-CoV-2PreventionNeurosciencesAlzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)Stem Cell ResearchAdenosine MonophosphateBrain DisordersEmerging Infectious DiseasesGood Health and Well BeingNerve DegenerationSynapsesDementiaDevelopmental Biology

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment

10.6084/m9.figshare.14759694.v1figshare

Additional file 1 of Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment

10.6084/m9.figshare.14759694figshare

Additional file 5 of Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment

10.6084/m9.figshare.14759706.v1figshare

Additional file 5 of Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment

10.6084/m9.figshare.14759706figshare

Additional file 1 of APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study

10.6084/m9.figshare.17468360.v1figshare

Additional file 1 of APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study

10.6084/m9.figshare.17468360figshare

Additional file 1 of In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variants

10.6084/m9.figshare.20921251.v1figshare

Additional file 1 of In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variants

10.6084/m9.figshare.20921251figshare

Additional file 1 of SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier

10.6084/m9.figshare.24432018.v1figshare

Additional file 1 of SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier

10.6084/m9.figshare.24432018figshare

Additional file 1 of ApoE4 associated with severe COVID-19 outcomes via downregulation of ACE2 and imbalanced RAS pathway

10.6084/m9.figshare.26567585.v1figshare

Additional file 1 of ApoE4 associated with severe COVID-19 outcomes via downregulation of ACE2 and imbalanced RAS pathway

10.6084/m9.figshare.26567585figshare