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Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis

Cell stem cell(2023)10.1016/j.stem.2023.02.010Source: DataRank Database

Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis is a research paper published in Cell stem cell (2023). On theSindex it has a DataRank of 0. It has been cited 68 times.

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Enrichment:Funding (15 grants)OA: hybridTopics (37)Linked Datasets (12)DataCite Reuse (12)IDs (PubMed, PMC)Annotations (2)

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Authors (7)

Connor J. Lennan,Mary Jean Sunshine ORCID,Daniela Dreifke,Ashu Chawla,Eric J. Bennett ORCID

Live enrichment

PubMed:36948186 PMC:PMC10164413

NIH HHS

Grant: S10 OD021831

NIGMS NIH HHS

Grant: R01 GM127681

NIDDK NIH HHS

Grant: R01 DK116951

NIDDK NIH HHS

Grant: R01 DK124775

NIH HHS

Grant: S10 OD032316

NCI NIH HHS

Grant: U01 CA267031

NCI NIH HHS

Grant: P30 CA023100

NCRR NIH HHS

Grant: S10 RR027366

National Institutes of Health

Grant: 1S10OD021831-01A1

Super-resolution confocal microscope

National Institutes of Health

Grant: 1R01DK116951-01

Protein Homeostasis in Hematopoietic Stem Cells

National Institutes of Health

Grant: 1S10RR027366-01A1

FACSAria II Cell Sorter

National Institutes of Health

Grant: 1R01DK124775-01

Ex vivo hematopoietic stem cell growth mediated by the heat shock response

National Institutes of Health

Grant: 3P30CA023100-25S4

Specialized Cancer Center Support Grant

National Institutes of Health

Grant: 5U01CA267031-02

The influence of proteostasis loss in aging hematopoietic stem cells on leukemia initiation

National Institutes of Health

Grant: 1S10OD032316-01

FACSymphony S6 Cell Sorter for Improving Basic, Clinical, and Translational Cancer Research Capabilities

hybridLicense: cc-by

publisherhttp://www.cell.com/article/S1934590923000711/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1934590923000711?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1934590923000711?httpAccept=text/plain

repositoryhttps://escholarship.org/content/qt6jz57666/qt6jz57666.pdf

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10164413/pdf/nihms-1885299.pdf

Fields of Study

0301 basic medicine03 medical and health sciences

MeSH Terms

Hematopoietic Stem CellsProteasome Endopeptidase ComplexTranscription FactorsAutophagyProteostasisMacroautophagy

Keywords

AgingStem cellHematopoietic stem cellProteasomeProtein degradationAutophagyProteostasisAggresomeBag3Aggrephagy570Proteasome Endopeptidase ComplexBiomedical and clinical sciences1.1 Normal biological development and functioning610Regenerative MedicineMedical and Health SciencesMacroautophagy2.1 Biological and endogenous factorsHematologyBiological SciencesStem Cell ResearchHematopoietic Stem CellsBloodStem Cell Research - Nonembryonic - Non-HumanBiochemistry and Cell BiologyGeneric health relevanceDevelopmental BiologyTranscription Factors

Additional file 1 of NXPH4 mediated by m5C contributes to the malignant characteristics of colorectal cancer via inhibiting HIF1A degradation

10.6084/m9.figshare.26793744.v1figshare

Additional file 1 of NXPH4 mediated by m5C contributes to the malignant characteristics of colorectal cancer via inhibiting HIF1A degradation

10.6084/m9.figshare.26793744figshare

Additional file 1 of Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthood

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Additional file 1 of Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthood

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Additional file 2 of Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthood

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Additional file 4 of Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthood

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Additional file 5 of Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthood

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Additional file 5 of Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthood

10.6084/m9.figshare.27022767.v1figshare

Additional file 4 of Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthood

10.6084/m9.figshare.27022764.v1figshare

Additional file 2 of Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthood

10.6084/m9.figshare.27022755.v1figshare

Additional file 3 of Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthood

10.6084/m9.figshare.27022758.v1figshare

Additional file 3 of Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthood

10.6084/m9.figshare.27022758figshare

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Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis

FAIR Checklist

Authors (7)

Funding (15 grants)

Open Access

Topics

Linked Datasets (12)

Annotations (Europe PMC)

Related Papers (10)