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A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Cell stem cell(2024)10.1016/j.stem.2024.02.004Source: DataRank Database

A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate is a research paper published in Cell stem cell (2024). On theSindex it has a DataRank of 0. It has been cited 60 times.

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Enrichment:Funding (26 grants)OA: hybridTopics (29)IDs (PubMed, PMC)Annotations (3)

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Authors (21)

Claudia Morganti ORCID,Nick van Gastel ORCID,Kyoko Ito ORCID,Enrica Calura ORCID,Ilaria Zanolla ORCID

Live enrichment

PubMed:38458178 PMC:PMC10957094

National Institutes of Health

Grant: R01HL069438

National Institutes of Health

Grant: R01HL148852

National Institutes of Health

Grant: R01DK98263

National Institutes of Health

Grant: R01DK115577

National Institutes of Health

Grant: R01 DK123181

National Institutes of Health

Grant: U54CA193461

National Institutes of Health

Grant: S10OD021624

National Institutes of Health

Grant: R01EB030061

National Cancer Institute

Grant: P30 CA013330

Leukemia & Lymphoma Society

Grant: DGP-24224-23

New York State Department of Health

Grant: C029154

Harvard Stem Cell Institute

Grant: 1360-19

Associazione Italiana per la Ricerca sul Cancro

Grant: MFAG 2019 23522

Associazione Italiana per la Ricerca sul Cancro

Grant: PRIN2017E5L5P3

NHLBI NIH HHS

Grant: P01 HL131477

NIDDK NIH HHS

Grant: R01 DK098263

National Institutes of Health

Grant: 5R01DK098263-13

The Roles of Lipid Metabolism in the Maintenance of Hematopoietic Stem Cells

National Institutes of Health

Grant: 5U54CA193461-04

Evolution and Treatment Response of Brain, Breast, and Hematologic Malignancies

National Institutes of Health

Grant: 5R01HL148852-03

Dissecting the canonical and non-canonical functions of Tet2 in hematopoietic stem cells and hematologic disorders

National Institutes of Health

Grant: 5R01EB030061-04

Probe-based two photon microscopy for functional, label-free early cancer diagnosis

National Institutes of Health

Grant: 5R01DK123181-02

Role of extracellular vesicles in the regulation of immunometabolism in obesity

National Institutes of Health

Grant: 5R01HL069438-20

In vivo mechanisms mediating sickle cell vaso-occlusion

National Institutes of Health

Grant: 1S10OD021624-01

Acquisition of Leica confocal/multiphoton microscope

National Institutes of Health

Grant: 3P30CA013330-39S3

Core Support for Cancer Center

Agios Pharmaceuticals

Alex's Lemonade Stand Foundation for Childhood Cancer

hybridLicense: CC BY NC ND

publisherhttps://api.elsevier.com/content/article/PII:S193459092400047X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S193459092400047X?httpAccept=text/plain

https://doi.org/10.1016/j.stem.2024.02.004

https://pubmed.ncbi.nlm.nih.gov/38458178

https://hdl.handle.net/2078.1/285589

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Hematopoietic Stem CellsNADPCell DifferentiationExtracellular VesiclesCell Self Renewal

Keywords

MitochondriaMetabolismCholesterolHematopoietic stem cellNADPHExosomesFatty Acid OxidationExtracellular VesiclesFate DeterminationHsc Self-renewal570cholesterol; exosomes; extracellular vesicles; fate determination; fatty acid oxidation; hematopoietic stem cell; HSC self-renewal; metabolism; mitochondria; NADPHhematopoietic stem cellmitochondriaNADPHcholesterolfatty acid oxidationfate determinationexosomesextracellular vesiclesmetabolismHSC self-renewal610Cell DifferentiationHematopoietic Stem CellsHSC self-renewal; NADPH; cholesterol; exosomes; extracellular vesicles; fate determination; fatty acid oxidation; hematopoietic stem cell; metabolism; mitochondriaexosomeextracellular vesicleCell Self RenewalNADP