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Gene Therapy of Dominant CRX-Leber Congenital Amaurosis using Patient Stem Cell-Derived Retinal Organoids

Stem Cell Reports(2021)10.1016/j.stemcr.2020.12.018Source: DataRank Database

Gene Therapy of Dominant CRX-Leber Congenital Amaurosis using Patient Stem Cell-Derived Retinal Organoids is a research paper published in Stem Cell Reports (2021). On theSindex it has a DataRank of 0. It has been cited 120 times.

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Open Access120 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (5 grants)OA: goldTopics (57)IDs (PubMed, PMC)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Zepeng Qu ORCID,James L. Gentry ORCID,Benjamin R. Fadl,Linn Gieser,Suja Hiriyanna

Live enrichment

PubMed:33513359 PMC:PMC7878833

Intramural NIH HHS

Grant: ZIA EY000546

Intramural NIH HHS

Grant: ZIA EY000450

National Institutes of Health

Grant: 1ZIAEY000450-15

Genetic and epigenetic regulation of retinal development, aging and evolution

National Institutes of Health

Grant: 1ZIAEY000546-09

Mechanisms, modeling and therapies of retinal and macular neurodegeneration

National Eye Institute

goldLicense: cc-by

publisherhttp://www.cell.com/article/S2213671120305130/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2213671120305130?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2213671120305130?httpAccept=text/plain

repositoryhttps://research-information.bris.ac.uk/ws/files/265967387/1_s2.0_S2213671120305130_main.pdf

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7878833

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

RetinaOrganoidsHumansDependovirusHomeodomain ProteinsTrans-ActivatorsSequence Analysis, RNACell DifferentiationPhenotypeMutationModels, BiologicalAdultChildChild, PreschoolFemalePhotoreceptor CellsOpsinsInduced Pluripotent Stem CellsLeber Congenital AmaurosisSingle-Cell AnalysisTranscriptomeGenetic Therapy

Keywords

Transcription factorTherapyAAVPluripotent stem cellsTranscriptomeRetinal degenerationDisease ModelingIpscScrna-seq3-D OrganoidsAdultInduced Pluripotent Stem CellsLeber Congenital Amaurosis610Models, BiologicalArticleRetinaHumansPhotoreceptor CellsChildHomeodomain ProteinsOpsinsSequence Analysis, RNACell DifferentiationGenetic TherapyDependovirusOrganoidsPhenotypeChild, PreschoolMutationFemaleSingle-Cell Analysis

Sustainable Development Goals

SDG 3: 3. Good health

Gene Therapy of Dominant CRX-Leber Congenital Amaurosis using Patient Stem Cell-Derived Retinal Organoids

FAIR Checklist

Authors (14)

Funding (5 grants)

Open Access

Topics

Annotations (Europe PMC)