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Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation

Stem Cell Reports(2021)10.1016/j.stemcr.2021.04.019Source: DataRank Database

Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation is a research paper published in Stem Cell Reports (2021). On theSindex it has a DataRank of 0. It has been cited 51 times.

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Open Access51 citations

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Enrichment:Funding (18 grants)Impact (FWCI 5.84)OA: goldTopics (79)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Meihong Zhang,Olivia T Ly ORCID,Hanna Chen,Arvind Sridhar ORCID,Erin Lambers

Live enrichment

PubMed:34019817 PMC:PMC8190590 OpenAlex:https://openalex.org/W3160941816

American Heart Association Inc

Grant: 19CDA34630041

National Center for Advancing Translational Sciences

Grant: UL1TR002003

Fondation Leducq

Grant: R01 HL148756

Fondation Leducq

Grant: R24 HL117756

Fondation Leducq

Grant: 18CVD05

National Institutes of Health

Grant: R01 HL126516

National Institutes of Health

Grant: T32 HL139439

National Institutes of Health

Grant: R01 HL148444

National Institutes of Health

Grant: R01 HL150586

National Institutes of Health

Grant: R01 GM139991

National Institutes of Health

Grant: 5T32HL139439-04

Training Program in Personalized Cardiovascular Medicine (TPIPCVM)

National Institutes of Health

Grant: 5UL1TR002003-08

Clinical and Translational Science Award

National Institutes of Health

Grant: 1R01HL148756-01A1

Rab GTPases-mediated mitochondrial clearance in diabetic cardiomyopathy

National Institutes of Health

Grant: 1R01HL126516-01

Integration Free IPS Cells-Derived Progenitors for Cardiac Regeneration

National Institutes of Health

Grant: 5R01GM139991-03

Regulation of Voltage-gated Proton Channel

National Institutes of Health

Grant: 5R24HL117756-03

Biorepository of Human iPSCs for Studying Dilated and Hypertrophic Cardiomyopathy

National Institutes of Health

Grant: 5R01HL150586-02

Human iPSC-derived atrial cardiomyocytes to model atrial fibrillation in a dish

National Institutes of Health

Grant: 5R01HL148444-04

Genotype-guided therapy for atrial fibrillation

FWCI

5.84

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttp://www.cell.com/article/S2213671121002149/pdf

publisherhttp://www.cell.com/article/S2213671121002149/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2213671121002149?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2213671121002149?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.stemcr.2021.04.019

Fields of Study

Cardiac electrophysiology and arrhythmiasAtrial Fibrillation Management and OutcomesCardiac Arrhythmias and Treatments0301 basic medicine03 medical and health sciencesAction PotentialsAtrial FibrillationElectrophysiologyGenetic Association StudiesHeart AtriaHumansInduced Pluripotent Stem CellsMaleMiddle AgedMutationMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelNitric OxidePedigreePhenotypeSignal TransductionSingle-Cell AnalysisTranscriptomeYoung Adult

MeSH Terms

Action PotentialsAtrial FibrillationElectrophysiologyHeart AtriaHumansMaleMiddle AgedMutationNitric OxidePedigreePhenotypeSignal TransductionMyocytes, CardiacYoung AdultGenetic Association StudiesInduced Pluripotent Stem CellsSingle-Cell AnalysisTranscriptomeNAV1.5 Voltage-Gated Sodium Channel

Keywords

BiologyNitric oxideInduced pluripotent stem cellAtrial fibrillationMediatorMutationStem cellSignal transductionInternal medicinePharmacologyCell biologyCardiologyGeneticsGeneEndocrinologyEmbryonic stem cellMedicineMutationsCardiac Sodium ChannelIpscsMaleInduced Pluripotent Stem CellsAction PotentialsMiddle AgedArticleNAV1.5 Voltage-Gated Sodium ChannelPedigreeElectrophysiologyYoung AdultPhenotypeHumansMyocytes, CardiacHeart AtriaSingle-Cell AnalysisTranscriptomeGenetic Association Studies

Sustainable Development Goals

SDG 0: Good health and well-being

Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation

FAIR Checklist

Authors (14)

Funding (18 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)