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Telmisartan is neuroprotective in a hiPSC-derived spinal microtissue model for C9orf72 ALS via inhibition of neuroinflammation

Stem Cell Reports(2025)10.1016/j.stemcr.2025.102535Source: DataRank Database

Telmisartan is neuroprotective in a hiPSC-derived spinal microtissue model for C9orf72 ALS via inhibition of neuroinflammation is a research paper published in Stem Cell Reports (2025). On theSindex it has a DataRank of 0. It has been cited 8 times.

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Open Access8 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (8 grants)Impact (FWCI 5.63)OA: goldTopics (50)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (15)

Björn F. Vahsen ORCID,Mario Ledesma-Terrón ORCID,Zhuoning Li ORCID,Laura Tuffery,Nan Xu ORCID

Live enrichment

PubMed:40541176 PMC:PMC12277806 OpenAlex:https://openalex.org/W4411451046

US Department of Defense

Grant: AL200169 - W81XWH2110140

National Institute of Mental Health

Grant: R01MH135403

Motor Neurone Disease Association

Grant: Talbot/Apr22/889-791

National Institutes of Health

Grant: P30CA08748

National Institute of Neurological Disorders and Stroke

Grant: R21NS116545

Charles H. Revson Foundation

Grant: 2020/30766/ZONMW

NCI NIH HHS

Grant: P30 CA008748

Boehringer Ingelheim Fonds

FWCI

5.63

Citation Percentile

1.0%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1016/j.stemcr.2025.102535

publisherhttps://doi.org/10.1016/j.stemcr.2025.102535

publisherhttps://api.elsevier.com/content/article/PII:S2213671125001390?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2213671125001390?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40541176

Fields of Study

Amyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders ResearchHistone Deacetylase Inhibitors ResearchTelmisartanHumansInduced Pluripotent Stem CellsAmyotrophic Lateral SclerosisNeuroprotective AgentsMicrogliaMotor NeuronsC9orf72 ProteinSpinal CordNeuroinflammatory DiseasesInflammationAstrocytesAngiotensin II Type 1 Receptor Blockers

MeSH Terms

C9orf72 ProteinTelmisartanNeuroinflammatory DiseasesAmyotrophic Lateral SclerosisAstrocytesHumansInflammationMotor NeuronsSpinal CordMicrogliaNeuroprotective AgentsAngiotensin II Type 1 Receptor BlockersInduced Pluripotent Stem Cells

Keywords

NeuroinflammationTelmisartanAmyotrophic lateral sclerosisNeuroprotectionMicrogliaC9orf72PharmacologyBiologyInflammationNeuroscienceMedicineImmunologyInternal medicineDiseaseEndocrinologyMotor neuronsAstrocytesSartansDrug Screen3D MicrotissueTriculture

Sustainable Development Goals

SDG 0: Zero hunger