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Tandem engagement of phosphotyrosines by the dual SH2 domains of p120RasGAP

Structure(2022)10.1016/j.str.2022.10.009Source: DataRank Database

Tandem engagement of phosphotyrosines by the dual SH2 domains of p120RasGAP is a research paper published in Structure (2022). On theSindex it has a DataRank of 0.416. It has been cited 8 times, with 4 citing works in its 1-hop citation network.

N/A

0.416DataRank · unranked

Scored on demand from live citation data

Open Access8 citations · 4 citing works in its network

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Linked data & code

uniprot pdb

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (18 grants)Impact (FWCI 0.55)OA: greenTopics (30)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 79%Citation Network 21%

Base Score Contribution

0.330

From this paper's citation signal

Citation Network Contribution

0.0862

From 3 citing papers with measurable signal

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Top 4 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 4 citers.

SH2db, an information system for the SH2 domain
Nucleic Acids Research202310 citations61 referencesContributes 0.039
An intramolecular energetic network regulates ligand recognition in a SH2 domain
Protein Science20237 citations53 referencesContributes 0.039
SHP2–EGFR States in Dephosphorylation Can Inform Selective SHP2 Inhibitors, Dampening RasGAP Action
The Journal of Physical Chemistry B20246 citations85 referencesContributes 0.023
Advanced MD Simulation Methods Uncover Mechanisms of SH3 Domain Functions in Small GTPase Signaling
Proteins Structure Function and Bioinformatics20250 citations59 referencesContributes 0.000

Authors (3)

Kimberly J. Vish ORCID,Titus J. Boggon ORCID,Amy L. Stiegler ORCID

Live enrichment

PubMed:36417908 PMC:PMC9722645 OpenAlex:https://openalex.org/W4309679224

NIGMS

Grant: R01GM102262

NIGMS

Grant: R01GM138411

NINDS

Grant: R01NS117609

NIGMS NIH HHS

Grant: P30 GM138395

NIH HHS

Grant: S10 OD018090

NIGMS NIH HHS

Grant: T32 GM008283

NIGMS NIH HHS

Grant: P41 GM103622

NIGMS NIH HHS

Grant: P30 GM124165

NHLBI NIH HHS

Grant: F31 HL165968

National Institutes of Health

Grant: 5T32GM008283-30

Predoctoral Program in Biophysics

National Institutes of Health

Grant: 3R01GM102262-06S1

Specificity and regulation in a protein kinase cascade affecting the actin cytoskeleton

National Institutes of Health

Grant: 5R01NS117609-04

Human Genetics and Molecular Mechanisms of Vein of Galen Aneurysmal Malformation

National Institutes of Health

Grant: 1F31HL165968-01

Structural Investigation of p120RasGAP's regulation by phosphorylated binding partners

National Institutes of Health

Grant: 1P30GM138395-01

The Biophysics Collaborative Access Team

National Institutes of Health

Grant: 1S10OD018090-01

Advanced Pixel Array Detector for Time-Resolved SAXS and Fiber Diffraction

National Institutes of Health

Grant: 3P30GM124165-03S1

NE-CAT: A Resource for Advanced Macromolecular Crystallography

National Institutes of Health

Grant: 5R01GM138411-03

P21-activated kinases in cell-cell and cell-matrix adhesion signaling

NHLBI

FWCI

0.55

Citation Percentile

0.6%

Citation Trend

2023

2024

2025

2026

greenLicense: Elsevier Non-Commercial

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9722645

publisherhttps://api.elsevier.com/content/article/PII:S0969212622004488?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0969212622004488?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.str.2022.10.009

Fields of Study

Protein Kinase Regulation and GTPase SignalingEnzyme Structure and FunctionMelanoma and MAPK Pathways0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Tyrosinesrc Homology DomainsPhosphotyrosineGTPase-Activating Proteinsp120 GTPase Activating Protein

Keywords

SH2 domainProto-oncogene tyrosine-protein kinase SrcSH3 domainTyrosineChemistryGTPaseCell biologyBiophysicsBiochemistryBiologyPhosphorylationPhosphotyrosineProtein-protein interactionSaxsRas SignalingItcsrc Homology DomainsGTPase-Activating Proteinsp120 GTPase Activating Protein

Tandem engagement of phosphotyrosines by the dual SH2 domains of p120RasGAP

FAIR Checklist

DataRank Breakdown

Top 4 citers driving the network score

Authors (3)

Funding (18 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)