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Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4

Structure(2024)10.1016/j.str.2024.02.019Source: DataRank Database

Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4 is a research paper published in Structure (2024). On theSindex it has a DataRank of 0. It has been cited 10 times.

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Open Access10 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (14 grants)Impact (FWCI 2.83)OA: bronzeTopics (61)IDs (PubMed, PMC, OpenAlex)Annotations (4)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Linghang Peng ORCID,Deli Huang ORCID,Amanda L. Gavin ORCID,Fangkun Luan,Jenny Tran

Live enrichment

PubMed:38537643 PMC:PMC11162324 OpenAlex:https://openalex.org/W4393190888

NCI

Grant: ACB-12002

Argonne National Laboratory

Grant: DE-AC02-06CH11357

NIGMS

Grant: AGM-12006

NIAID NIH HHS

Grant: R01 AI142945

NIA NIH HHS

Grant: RF1 AG070775

National Institutes of Health

Grant: 5R01AI142945-03

Functions of novel phospholipase D proteins in nucleic acid sensing

National Institutes of Health

Grant: 1RF1AG070775-01A1

Role of PLD3 in nucleic acid recognition and brain function

National Institutes of Health

Grant: 5F32GM012006-03

MOLECULAR GENETIC ANALYSIS OF THE DROSOPHILA 205K MAP

NIA

U.S. Department of Energy

Skaggs Institute for Chemical Biology, Scripps Research Institute

National Institutes of Health

NIAID

Office of Science

FWCI

2.83

Citation Percentile

0.9%

Citation Trend

2024

2025

bronzeLicense: CC BY

journalhttp://www.cell.com/article/S0969212624000790/pdf

publisherhttp://www.cell.com/article/S0969212624000790/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0969212624000790?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0969212624000790?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.str.2024.02.019

Fields of Study

Calcium signaling and nucleotide metabolismCellular transport and secretionSphingolipid Metabolism and Signaling0301 basic medicine03 medical and health sciencesPhospholipase DHumansCatalytic DomainModels, MolecularSubstrate SpecificityCrystallography, X-RayMutationLysosomesPhosphorylationDNA, Single-StrandedProtein MultimerizationProtein BindingExodeoxyribonucleases

MeSH Terms

DNA, Single-StrandedExodeoxyribonucleasesHumansLysosomesModels, MolecularMutationPhospholipase DPhosphorylationProtein BindingSubstrate SpecificityCrystallography, X-RayCatalytic DomainProtein Multimerization

Keywords

Phosphodiester bondBiochemistryTrimerChemistryEnzymeActive siteThermostabilityBiologyDimerGeneCrystal structureTlr SignalingExonucleaseDisease-associated MutationsPld3Pld4Models, MolecularDNA, Single-StrandedCrystallography, X-RayArticleSubstrate SpecificityExodeoxyribonucleasesCatalytic DomainMutationPhospholipase DHumansPhosphorylationProtein MultimerizationLysosomesProtein Binding

Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4

FAIR Checklist

Authors (11)

Funding (14 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)