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Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM

Structure(2024)10.1016/j.str.2024.11.018Source: DataRank Database

Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM is a research paper published in Structure (2024). On theSindex it has a DataRank of 0. It has been cited 5 times.

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Open Access5 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (11 grants)Impact (FWCI 0.96)OA: greenTopics (57)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Takuya Kobayashi ORCID,Takashi Murayama ORCID,Montserrat Samsó ORCID,Kavita A. Iyer ORCID

Live enrichment

PubMed:39708816 PMC:PMC11805659 OpenAlex:https://openalex.org/W4405638761

National Institute of General Medical Sciences

Grant: U24 GM116789

National Institute of General Medical Sciences

Grant: U24 GM116790

American Heart Association Inc

Grant: 19POST34430178

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Grant: R01 AR068431

Research Center for Biomedical Engineering

Grant: 4001

Japan Society for the Promotion of Science

Grant: 19H03404

Japan Society for the Promotion of Science

Grant: 22H02805

NCRR NIH HHS

Grant: S10 RR025067

National Center of Neurology and Psychiatry

National Institutes of Health

Naito Foundation

FWCI

0.96

Citation Percentile

0.7%

Citation Trend

2025

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11805659/

publisherhttps://api.elsevier.com/content/article/PII:S0969212624005318?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0969212624005318?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.str.2024.11.018

Fields of Study

Ion channel regulation and functionCardiac electrophysiology and arrhythmiasErythrocyte Function and PathophysiologyDantroleneRyanodine Receptor Calcium Release ChannelCryoelectron MicroscopyMalignant HyperthermiaHumansCalciumModels, MolecularProtein BindingMutationBinding SitesMuscle Relaxants, CentralIon Channel GatingAnimals

MeSH Terms

AnimalsBinding SitesCalciumDantroleneHumansMalignant HyperthermiaModels, MolecularMuscle Relaxants, CentralMutationProtein BindingRyanodineIon Channel GatingRyanodine Receptor Calcium Release ChannelCryoelectron MicroscopyHEK293 Cells

Keywords

DantroleneRyanodine receptorMalignant hyperthermiaRYR1ReceptorMutationChemistryCell biologyBiophysicsCancer researchBiologyBiochemistryMedicineInternal medicinePathologyCalciumCalcium channelsProtein conformationIon channelExcitation-contraction couplingSkeletal musclemuscle spasticityHydantoinCentral Core DiseaseAllosteric SiteIon Channel Gating

Sustainable Development Goals

SDG 0: Good health and well-being