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Structural basis for substrate binding, catalysis, and inhibition of cancer target mitochondrial creatine kinase by a covalent inhibitor

Structure(2025)10.1016/j.str.2025.01.008Source: DataRank Database

Structural basis for substrate binding, catalysis, and inhibition of cancer target mitochondrial creatine kinase by a covalent inhibitor is a research paper published in Structure (2025). On theSindex it has a DataRank of 0. It has been cited 5 times.

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0DataRank · unranked

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Open Access5 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 2.03)OA: greenTopics (37)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Laura Koepping ORCID,Ya Li ORCID,L. Miya Fujimoto ORCID,Andrey A. Bobkov ORCID,Jianhua Zhao ORCID

Live enrichment

PubMed:39904336 PMC:PMC11972147 OpenAlex:https://openalex.org/W4407086764

Conrad Prebys Foundation

Grant: CPF #651

NIH NCI

Grant: R01 CA251910

NIH NCI

Grant: S10 OD026926

NIH NCI

Grant: P30 CA030199

NIGMS NIH HHS

Grant: R35 GM147487

National Institutes of Health

FWCI

2.03

Citation Percentile

0.9%

Citation Trend

2025

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11972147/

publisherhttps://api.elsevier.com/content/article/PII:S0969212625000085?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0969212625000085?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.str.2025.01.008

Fields of Study

Biochemical and Molecular ResearchCancer, Hypoxia, and MetabolismEnzyme Structure and FunctionMedicineChemistry

MeSH Terms

Breast NeoplasmsCreatineHumansMitochondriaModels, MolecularProtein BindingSubstrate SpecificityCrystallography, X-RayCatalytic DomainProtein Kinase InhibitorsCell ProliferationCreatine Kinase, Mitochondrial Form

Keywords

Covalent bondChemistryCreatine kinaseCovalent bindingKinaseBiochemistrySubstrate (aquarium)StereochemistryCatalysisBiophysicsEnzymeBiologyOrganic chemistrysteady-state kineticsEnzyme MechanismEnergy HomeostasisCryo-emChemical ProbesMitochondrial Creatine KinaseHer2+ Breast Cancer

Structural basis for substrate binding, catalysis, and inhibition of cancer target mitochondrial creatine kinase by a covalent inhibitor

FAIR Checklist

Authors (8)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)