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High throughput mutational characterization of the GPCR ligand C5a using yeast display and deep sequencing

Structure(2025)10.1016/j.str.2025.10.002Source: DataRank Database

High throughput mutational characterization of the GPCR ligand C5a using yeast display and deep sequencing is a research paper published in Structure (2025). On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)Impact (FWCI 0.00)OA: greenTopics (26)IDs (PubMed, OpenAlex)

FAIR Checklist

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (28)

Kaushik N. Thakkar ORCID,Li Guan ORCID,Yu Rebecca Miao ORCID,Manal Mehibel,Robert Lee ORCID

Live enrichment

PubMed:41151574 OpenAlex:https://openalex.org/W4415596677

National Institutes of Health Office of the Director

Grant: R35GM128641

National Institutes of Health Office of the Director

Grant: / NCI P01 CA257907

NCI NIH HHS

Grant: P01 CA257907

National Institutes of Health

FWCI

0.00

Citation Percentile

0.2%

greenLicense: cc-by

publisherhttps://api.elsevier.com/content/article/PII:S0969212625003892?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0969212625003892?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.str.2025.10.002

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41151574

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12671449/

Fields of Study

Receptor Mechanisms and SignalingMonoclonal and Polyclonal Antibodies ResearchPancreatic function and diabetes

MeSH Terms

Binding SitesHumansLigandsModels, MolecularMutationProtein BindingSaccharomyces cerevisiaeComplement C5aReceptor, Anaphylatoxin C5aHigh-Throughput Nucleotide Sequencing

Keywords

G protein-coupled receptorMutagenesisLigand (biochemistry)Two-hybrid screeningC5a receptorYeastReceptorProtein–protein interactionMembrane proteinYeast surface displayHigh throughput screeningG Protein Coupled ReceptorsSite Saturation Mutagenesis