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Exposure to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine under hypoxic conditions (%O2 =2 %) alters differential gene expression and mitigates decreased invasion capacity, compared to normoxic conditions (%O2 ≥ 21 %) in HTR-8/SVneo cells

Toxicology Letters(2025)10.1016/j.toxlet.2025.111773Source: DataRank Database

Exposure to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine under hypoxic conditions (%O2 =2 %) alters differential gene expression and mitigates decreased invasion capacity, compared to normoxic conditions (%O2 ≥ 21 %) in HTR-8/SVneo cells is a research paper published in Toxicology Letters (2025). On theSindex it has a DataRank of 0.

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Enrichment:Funding (5 grants)Impact (FWCI 0.00)OA: hybridTopics (38)IDs (PubMed, PMC, OpenAlex)Annotations (1)

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Context only (not used in score)

Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (3)

Ngoc Tram Anh Le,Elana R. Elkin ORCID,Franny H. Stein

Live enrichment

PubMed:41232580 PMC:PMC12851871 OpenAlex:https://openalex.org/W4416451767

National Institute on Minority Health and Health Disparities

Grant: U54MD012397

National Institute of Environmental Health Sciences

Grant: K01ES036552

NIMHD NIH HHS

Grant: S21 MD010690

San Diego State University

National Institutes of Health

FWCI

0.00

Citation Percentile

0.4%

hybridLicense: cc-by

journalhttps://doi.org/10.1016/j.toxlet.2025.111773

publisherhttps://doi.org/10.1016/j.toxlet.2025.111773

publisherhttps://api.elsevier.com/content/article/PII:S0378427425027195?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0378427425027195?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41232580

Fields of Study

Pregnancy and preeclampsia studiesEffects and risks of endocrine disrupting chemicalsCarcinogens and Genotoxicity AssessmentHumansTrichloroethyleneTrophoblastsCysteineCell LineFemalePregnancyCell HypoxiaCell MovementCell Survival

MeSH Terms

Cell LineCell MovementCell SurvivalCysteineFemaleHumansPregnancyTrichloroethyleneTrophoblastsCell Hypoxia

Keywords

MetaboliteGene expressionHypoxia (environmental)TrichloroethyleneFetusPlacentaCytotoxicityCell cultureRegulation of gene expressionHypoxiaInvasionTrophoblastsTrichloroethylene (Tce)2-Dichlorovinyl)-l-cysteine (Dcvc)S-(1

Exposure to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine under hypoxic conditions (%O2 =2 %) alters differential gene expression and mitigates decreased invasion capacity, compared to normoxic conditions (%O2 ≥ 21 %) in HTR-8/SVneo cells

FAIR Checklist

Authors (3)

Funding (5 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)