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IL-6 amplifies corneal transplant alloimmunity by inducing dysfunctional IFN-γ- secreting Treg through the VEGFA-VEGFR1 axis

Transplant Immunology(2025)10.1016/j.trim.2025.102284Source: DataRank Database

IL-6 amplifies corneal transplant alloimmunity by inducing dysfunctional IFN-γ- secreting Treg through the VEGFA-VEGFR1 axis is a research paper published in Transplant Immunology (2025). On theSindex it has a DataRank of 0.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (2 grants)Impact (FWCI 0.00)OA: greenTopics (45)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Akitomo Narimatsu ORCID,Neda Heydarian,Mark Krauthammer,Shilpy Bhullar ORCID,Yihe Chen ORCID

Live enrichment

PubMed:40907721 OpenAlex:https://openalex.org/W4413922717

NIH

Grant: R01EY012963

National Eye Institute

FWCI

0.00

Citation Percentile

0.3%

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12486648/

publisherhttps://api.elsevier.com/content/article/PII:S0966327425001121?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0966327425001121?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.trim.2025.102284

Fields of Study

Corneal surgery and disordersCorneal Surgery and TreatmentsOcular Surface and Contact LensT-Lymphocytes, RegulatoryCorneal TransplantationVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1AnimalsInterferon-gammaInterleukin-6MiceGraft RejectionMice, Inbred BALB CGraft SurvivalHumansMice, Inbred C57BLCells, CulturedForkhead Transcription FactorsCornea

MeSH Terms

AnimalsCells, CulturedCorneaGraft RejectionGraft SurvivalHumansInterferon-gammaMice, Inbred BALB CMice, Inbred C57BLInterleukin-6Corneal TransplantationVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth Factor AT-Lymphocytes, RegulatoryMiceForkhead Transcription Factors

Keywords

AlloimmunityDysfunctional familyImmunologyMedicineImmune systemCorneal transplantationimmune privilegeIl-6 SignalingDysfunctional TregVegfa–vegfr1 Axis