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RAS/MAPK Pathway Driver Alterations Are Significantly Associated With Oncogenic KIT Mutations in Germ-cell Tumors

Urology(2020)10.1016/j.urology.2020.07.027Source: DataRank Database

RAS/MAPK Pathway Driver Alterations Are Significantly Associated With Oncogenic KIT Mutations in Germ-cell Tumors is a research paper published in Urology (2020). On theSindex it has a DataRank of 0.591. It has been cited 13 times, with 13 citing works in its 1-hop citation network.

N/A

0.591DataRank · unranked

Scored on demand from live citation data

Open Access13 citations · 13 citing works in its network

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Linked data & code

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 1.18)OA: greenTopics (86)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 67%Citation Network 33%

Base Score Contribution

0.396

From this paper's citation signal

Citation Network Contribution

0.195

From 8 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 13 citers.

A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
Cell Reports202237 citations64 referencesContributes 0.057
Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors
Oncogene202216 citations54 referencesContributes 0.052
Defining the cellular origin of seminoma by transcriptional and epigenetic mapping to the normal human germline
Cell Reports202413 citations88 referencesContributes 0.030
Molecular Biology of Pediatric and Adult Male Germ Cell Tumors
Cancers202120 citations118 referencesContributes 0.026
Biomarkers for Salvage Therapy in Testicular Germ Cell Tumors
International Journal of Molecular Sciences20239 citations95 referencesContributes 0.024

Authors (16)

Soo‐Ryum Yang ORCID,Donna C. Ferguson,Ying Liu ORCID,Rohit Sharma ORCID,Jamal Benhamida ORCID

Live enrichment

PubMed:32721511 PMC:PMC8276690 OpenAlex:https://openalex.org/W3044671850

National Institutes of Health

Grant: P30 CA008748

National Institutes of Health

Grant: 2P30CA008748-43

MOUSE GENETICS

National Cancer Institute

FWCI

1.18

Citation Percentile

0.8%

Influential Citations

Citation Trend

2020

2021

2022

2023

2024

2025

2026

greenLicense: Elsevier TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8276690

GREENhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276690

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8276690

publisherhttps://api.elsevier.com/content/article/PII:S009042952030889X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S009042952030889X?httpAccept=text/plain

Fields of Study

Testicular diseases and treatmentsGastrointestinal Tumor Research and TreatmentSarcoma Diagnosis and TreatmentMedicine0301 basic medicine03 medical and health sciences0302 clinical medicineAdolescentAdultAntineoplastic Combined Chemotherapy ProtocolsChildDNA Mutational AnalysisFemaleFollow-Up StudiesHumansMAP Kinase Kinase 1MAP Kinase Signaling SystemMaleMiddle AgedMutationNeoplasms, Germ Cell and EmbryonalProtein Kinase InhibitorsProto-Oncogene Proteins c-kitRetrospective StudiesSeminomaTesticular NeoplasmsYoung Adultras ProteinsNonseminomatous germ cell tumor

MeSH Terms

AdolescentAdultAntineoplastic Combined Chemotherapy ProtocolsChildDNA Mutational AnalysisFemaleFollow-Up StudiesHumansMaleMiddle AgedMutationNeoplasms, Germ Cell and EmbryonalRetrospective StudiesTesticular NeoplasmsSeminomaras ProteinsProto-Oncogene Proteins c-kitMAP Kinase Signaling SystemProtein Kinase InhibitorsMAP Kinase Kinase 1Young Adult

Keywords

Neuroblastoma RAS viral oncogene homologKRASMedicineHazard ratioCancer researchCancerGerm cell tumorsConfidence intervalTargeted therapyOncologyInternal medicineGermline mutationMutationChemotherapyGeneGeneticsBiologyAdultMaleAdolescentMAP Kinase Signaling SystemDNA Mutational AnalysisMAP Kinase Kinase 1Middle AgedNeoplasms, Germ Cell and EmbryonalSeminomaProto-Oncogene Proteins c-kitYoung AdultTesticular NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsHumansFemaleChildProtein Kinase InhibitorsFollow-Up StudiesRetrospective Studies

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being