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Muscle-Directed Delivery of an AAV1 Vector Leads to Capsid-Specific T Cell Exhaustion in Nonhuman Primates and Humans

Molecular Therapy(2020)10.1016/j.ymthe.2020.01.004Source: DataRank Database

Muscle-Directed Delivery of an AAV1 Vector Leads to Capsid-Specific T Cell Exhaustion in Nonhuman Primates and Humans is a research paper published in Molecular Therapy (2020). On theSindex it has a DataRank of 0. It has been cited 43 times.

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Enrichment:Funding (7 grants)OA: hybridTopics (55)IDs (PubMed, PMC)Annotations (1)SDGs (1)

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Authors (6)

Alisha M. Gruntman ORCID,Meghan Blackwood ORCID,Marina Zieger ORCID,Terence R. Flotte ORCID,Christian Mueller ORCID

Live enrichment

PubMed:31982038 PMC:PMC7054721

National Heart, Lung, and Blood Institute

Grant: P01 HL131471

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: R01 DK098252

National Institutes of Health

Grant: 4R01DK098252-04

Dual-function vectors for in vivo gene therapy of AAT Liver disease

National Institutes of Health

Grant: 5P01HL131471-02

New Approaches to Gene Therapy for Alpha-1 Antitrypsin Deficiency

Applied Genetic Technologies Corporation

Alpha-1 Foundation

National Institutes of Health

hybridLicense: CC BY NC ND

Europe_PMChttps://europepmc.org/articles/PMC7054721

Europe_PMChttps://europepmc.org/articles/PMC7054721?pdf=render

https://doi.org/10.1016/j.ymthe.2020.01.004

http://www.cell.com/article/S1525001620300101/pdf

https://pubmed.ncbi.nlm.nih.gov/31982038

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

MusclesAnimalsMacaca mulattaHumansDependovirusCapsid ProteinsLymphocyte CountInjections, IntramuscularGene Transfer TechniquesTransduction, GeneticOrgan SpecificityImmunity, CellularGene ExpressionTransgenesGenetic VectorsT-Lymphocytes, RegulatoryImmunity, Humoral

Keywords

Gene therapyToleranceGene transferImmunityAdeno-associated virusAAVExhaustionTregsRegulatory T cellsExhausted T cellsGenetic VectorsGene ExpressionInjections, IntramuscularT-Lymphocytes, Regulatoryregulatory T cellsTransduction, GeneticAnimalsHumansLymphocyte CountTransgenesMolecular BiologyDiagnostic and Therapeutic Techniques and EquipmentImmunity, CellularMusclesGene Transfer TechniquesGenetics and GenomicsAnalyticalDependovirusMacaca mulattaImmunity, Humoralexhausted T cellsOrgan SpecificityVirusesOriginal ArticleCapsid Proteins

Sustainable Development Goals

SDG 3: 3. Good health

Muscle-Directed Delivery of an AAV1 Vector Leads to Capsid-Specific T Cell Exhaustion in Nonhuman Primates and Humans

FAIR Checklist

Authors (6)

Funding (7 grants)

Open Access

Topics

Annotations (Europe PMC)