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AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9

Molecular Therapy(2020)10.1016/j.ymthe.2020.04.017Source: DataRank Database

AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9 is a research paper published in Molecular Therapy (2020). On theSindex it has a DataRank of 5.8. It has been cited 229 times, with 200 citing works in its 1-hop citation network.

N/A

5.8DataRank · unranked

Scored on demand from live citation data

Open Access229 citations · 200 citing works in its network

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doi

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (20 grants)Impact (FWCI 10.76)OA: hybridTopics (83)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 14%Citation Network 86%

Base Score Contribution

0.816

From this paper's citation signal

Citation Network Contribution

5.0

From 177 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 200 citers.

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Science Advances2021215 citations37 referencesContributes 0.145
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Nature Communications202126 citations23 referencesContributes 0.143

Authors (11)

Mark R. Tanner ORCID,Ciaran M. Lee ORCID,Ayrea Hurley ORCID,Marco De Giorgi ORCID,Kelsey E. Jarrett ORCID

Live enrichment

PubMed:32348718 PMC:PMC7264438 OpenAlex:https://openalex.org/W3016959969

American Heart Association

Grant: 19POST34430092

American Heart Association

Grant: 19PRE34380467

American Heart Association

Grant: GM08231

American Heart Association

Grant: HL007676

American Heart Association

Grant: RR024574

Cancer Prevention and Research Institute of Texas

Grant: RR140081

Cancer Prevention and Research Institute of Texas

Grant: RP180672

National Institutes of Health

Grant: CA125123

National Institutes of Health

Grant: UG3HL151545

National Institutes of Health

Grant: HL132840

National Institutes of Health

Grant: U42OD026645

NCRR NIH HHS

Grant: S10 RR024574

NIGMS NIH HHS

Grant: T32 GM008231

NHLBI NIH HHS

Grant: R01 HL132840

NCI NIH HHS

Grant: P30 CA125123

NHLBI NIH HHS

Grant: T32 HL007676

National Institutes of Health

Grant: 2R01HL132840-06

Genetic Repair of Familial Hypercholesterolemia

National Institutes of Health

Grant: 3P30CA125123-09S3

Baylor College of Medicine Cancer Center

National Institutes of Health

Grant: 1U42OD026645-01

BCM-Rice resource for the analysis of somatic gene editing in mice

National Institutes of Health

Grant: 5UG3HL151545-02

Velcro AAV Vector for tissue-specific delivery of genome editing reagents with enhanced cargo capacity

FWCI

10.76

Citation Percentile

1.0%

Citation Trend

2019

2020

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by-nc-nd

journalhttp://www.cell.com/article/S1525001620301982/pdf

publisherhttp://www.cell.com/article/S1525001620301982/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1525001620301982?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1525001620301982?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.ymthe.2020.04.017

Fields of Study

CRISPR and Genetic EngineeringVirus-based gene therapy researchViral Infections and Immunology Research0301 basic medicine03 medical and health sciences

MeSH Terms

Gene EditingCRISPR-Associated Protein 9RNA, Guide, CRISPR-Cas SystemsDependovirusAnimalsGenetic VectorsHumansImmunizationImmunologic MemoryBiomarkersGene ExpressionImmunophenotypingT-Lymphocyte SubsetsRNA, Guide, KinetoplastidaTransgenesHepatocytesGene OrderMiceClustered Regularly Interspaced Short Palindromic Repeats

Keywords

Cas9CRISPRGenome editingBiologyGenomeGeneVirologyImmunityStreptococcus pyogenesGeneticsStaphylococcus aureusImmune systemBacteriaGene therapyLiverImmune responseHepatocytesAdeno-associated virusCd8+ T CellPre-existing ImmunitySacas9Somatic Genome EditingAav-crisprMedical SciencesGenetic StructuresGene ExpressionRNA, Guide, CRISPR-Cas SystemsBiochemistryMiceT-Lymphocyte SubsetsCRISPR-Associated Protein 9Gene OrderMedical SpecialtiesMedicine and Health SciencesClustered Regularly Interspaced Short Palindromic RepeatsTransgenesGene and molecular therapyGene EditingLife SciencesDependovirusOriginal ArticleGenetic PhenomenaMedical GeneticsGenetic Processes570Genetic VectorsBiophysics610ImmunophenotypingAnimalsHumansGenetics and Genomicsand Structural BiologyRNAImmunizationCRISPR-Cas SystemsImmunologic MemoryGuideBiomarkers

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being