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Transcriptional reprogramming restores UBE3A brain-wide and rescues behavioral phenotypes in an Angelman syndrome mouse model

Molecular Therapy(2023)10.1016/j.ymthe.2023.01.013Source: DataRank Database

Transcriptional reprogramming restores UBE3A brain-wide and rescues behavioral phenotypes in an Angelman syndrome mouse model is a research paper published in Molecular Therapy (2023). On theSindex it has a DataRank of 0. It has been cited 47 times.

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Enrichment:Funding (16 grants)OA: hybridTopics (43)IDs (PubMed, PMC)Annotations (3)

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Authors (16)

Ulrika Beitnere ORCID,Miranda S. Garcia,Anna Adhikari ORCID,David Cameron,Timothy A. Fenton ORCID

Live enrichment

PubMed:36641623 PMC:PMC10124086

National Center for Advancing Translational Sciences

Grant: TL1 TR001861

National Center for Advancing Translational Sciences

Grant: UL1 TR001860

CIRM

Grant: DISC2-09032

National Institute of Neurological Disorders and Stroke

Grant: R01NS097808

NIH

Grant: 1S10OD010786-01

Acquisition of Covaris E220 and Sciclone G3 systems for high throughput sequencin

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Grant: P50HD103526

NIH HHS

Grant: S10 OD010786

NIH HHS

Grant: R24 OD021606

NIGMS NIH HHS

Grant: T32 GM099608

National Institutes of Health

Grant: 5T32GM099608-04

Pharmacology Training: Bench to Bedside

National Institutes of Health

Grant: 3R24OD021606-03S1

Optimization of humanized mouse models using mobilized peripheral blood stem cells

National Institutes of Health

Grant: 5UL1TR001860-10

UC Davis Clinical and Translational Science Center

National Institutes of Health

Grant: 2TL1TR001861-06

NRSA Training Core (TL1)

National Institutes of Health

Grant: 5R01NS097808-04

Phenotypic Characterization of Novel Models of Dup15q Syndrome

National Institutes of Health

Grant: 5P50HD103526-03

MIND Institute Intellectual and Developmental Disabilities Research Center

Foundation for Angelman Syndrome Therapeutics Australia

hybridLicense: cc-by

publisherhttp://www.cell.com/article/S1525001623000138/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1525001623000138?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1525001623000138?httpAccept=text/plain

repositoryhttps://escholarship.org/content/qt5p62m8d8/qt5p62m8d8.pdf

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10124086/pdf/main.pdf

MeSH Terms

BrainAnimalsMiceAngelman SyndromeUbiquitin-Protein LigasesTranscription FactorsGene Expression RegulationPhenotype

Keywords

Zinc fingerImprintingAsAngelman SyndromeUbe3aAtfArtificial Transcription FactorEpigenome EditingAav TherapyBrain-wide DeliveryTechnologyIntellectual and Developmental Disabilities (IDD)Ubiquitin-Protein LigasesMedical BiotechnologyClinical Sciences610Medical and Health SciencesMiceRare DiseasesBehavioral and Social ScienceGeneticsAnimalsBiomedical and Clinical Sciences5.2 Cellular and gene therapiesNeurosciencesBrainGene TherapyBiological SciencesBrain DisordersOrphan DrugPhenotypeGene Expression RegulationNeurologicalBiotechnologyTranscription Factors

Transcriptional reprogramming restores UBE3A brain-wide and rescues behavioral phenotypes in an Angelman syndrome mouse model

FAIR Checklist

Authors (16)

Funding (16 grants)

Open Access

Topics

Annotations (Europe PMC)