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SOCS3 regulates pathological retinal angiogenesis through modulating SPP1 expression in microglia and macrophages

Molecular Therapy(2024)10.1016/j.ymthe.2024.03.025Source: DataRank Database

SOCS3 regulates pathological retinal angiogenesis through modulating SPP1 expression in microglia and macrophages is a research paper published in Molecular Therapy (2024). On theSindex it has a DataRank of 0.835. It has been cited 25 times, with 22 citing works in its 1-hop citation network.

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0.835DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access25 citations · 22 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE227861

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (17 grants)Impact (FWCI 9.91)OA: greenTopics (64)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 59%Citation Network 41%

Base Score Contribution

0.489

From this paper's citation signal

Citation Network Contribution

0.346

From 13 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 22 citers.

Single-cell analysis identifies MKI67+ microglia as drivers of neovascularization in proliferative diabetic retinopathy
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Tetrahydrocurcumin alleviates colorectal tumorigenesis by modulating the SPP1/CD44 axis and preventing M2 tumor-associated macrophage polarization
Phytomedicine202518 citations65 referencesContributes 0.045
H4K12 Lactylation Activated‐ Spp1 in Reprogrammed Microglia Improves Functional Recovery After Spinal Cord Injury
CNS Neuroscience & Therapeutics202513 citations78 referencesContributes 0.034
Identification and validation of potential shared diagnostic markers for sepsis-induced ARDS and cardiomyopathy via WGCNA and machine learning
Frontiers in Molecular Biosciences20253 citations42 referencesContributes 0.033
SPP1 as a key modulator of M2 macrophage polarization promotes endometriosis progression via activation of the FAK/PI3K/AKT pathway: A bioinformatics and experimental study
International Immunopharmacology20254 citations51 referencesContributes 0.032

Authors (18)

Satoshi Kaneko ORCID,Emil Kriukov,David Álvarez ORCID,Enton Lam,Yidi Wang ORCID

Live enrichment

PubMed:38504518 PMC:PMC11081920 OpenAlex:https://openalex.org/W4392962882

Associazione Italiana per la Ricerca sul Cancro

Grant: 27378

Associazione Italiana per la Ricerca sul Cancro

Grant: IG 2022

National Eye Institute

Grant: U24EY029893

Medical Research Council

Grant: MR/W004681/1

National Institutes of Health

Grant: R01EY030140

National Institutes of Health

Grant: R01EY029238

National Institutes of Health

Grant: S10D030322

National Institutes of Health

Grant: P50 HD105351

NIAID NIH HHS

Grant: R01 AI175379

NEI NIH HHS

Grant: P30 EY003039

NHLBI NIH HHS

Grant: R01 HL146128

National Institutes of Health

Grant: 5U24EY029893-05

Retinal Ganglion Cell Replacement in Clinically Relevant Models of Optic Neuropathy

National Institutes of Health

Grant: 5R01HL146128-03

MSC Exosome Treatment for BPD: Impact on Immunity and Lung Development

National Institutes of Health

Grant: 5P50HD105351-02

Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center

National Institutes of Health

Grant: 5R01EY030140-04

The Mechanism of Immune-Vascular Crosstalk in Retinopathy

National Institutes of Health

Grant: 1R01EY029238-01A1

Photoreceptor Determination of Retinal Blood Vessel Growth in Retinopathy

NIH

FWCI

9.91

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

greenLicense: cc-by-nc-nd

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11081920/pdf/main.pdf

publisherhttps://api.elsevier.com/content/article/PII:S1525001624001667?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1525001624001667?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11081920

Fields of Study

Retinal Diseases and TreatmentsNeuroinflammation and Neurodegeneration Mechanismsinterferon and immune responses0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsMiceAngiogenesisDisease Models, AnimalGene Expression RegulationMacrophagesMice, KnockoutMicrogliaNeovascularization, PathologicOsteopontinRetinal NeovascularizationSignal TransductionSTAT3 Transcription FactorSuppressor of Cytokine Signaling 3 Protein

MeSH Terms

Suppressor of Cytokine Signaling 3 ProteinAngiogenesisAnimalsDisease Models, AnimalGene Expression RegulationMacrophagesNeovascularization, PathologicSignal TransductionRetinal NeovascularizationMicrogliaMice, KnockoutSTAT3 Transcription FactorMiceOsteopontin

Keywords

SOCS3AngiogenesisMicrogliaNeovascularizationBiologyCell biologySTAT proteinCancer researchSTAT3Signal transductionImmunologyInflammationMacrophagesretinopathySpp1Retinal AngiogenesisNeovascularization-associated MicrogliaSTAT3 Transcription Factor610Retinal NeovascularizationMiceAnimalsMice, KnockoutNeovascularization, PathologicSOCS3; SPP1; macrophages; microglia; neovascularization; neovascularization-associated microglia; retinal angiogenesis; retinopathyDisease Models, AnimalGene Expression RegulationSuppressor of Cytokine Signaling 3 ProteinOriginal ArticleOsteopontin

Sustainable Development Goals

SDG 0: Zero hunger