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High-dimensional temporal mapping of CAR T cells reveals phenotypic and functional remodeling during manufacturing

Molecular Therapy(2025)10.1016/j.ymthe.2025.04.006Source: DataRank Database

High-dimensional temporal mapping of CAR T cells reveals phenotypic and functional remodeling during manufacturing is a research paper published in Molecular Therapy (2025). On theSindex it has a DataRank of 0.915. It has been cited 41 times, with 38 citing works in its 1-hop citation network.

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0.915DataRank · unranked

Scored on demand from live citation data

Open Access41 citations · 38 citing works in its network

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (1 grants)OA: hybridTopics (31)IDs (PubMed, PMC)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 61%Citation Network 39%

Base Score Contribution

0.561

From this paper's citation signal

Citation Network Contribution

0.355

From 23 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 38 citers.

Cell avidity in CAR-T cell therapy
Expert Review of Molecular Diagnostics20253 citations21 referencesContributes 0.066
Divergent on-target off-tumor effects by CAR T and CAR NK cells suggest different efficacy and safety of cell therapies
OncoImmunology202511 citations55 referencesContributes 0.045
On-target/off-tumor toxicities following infusion of low-affinity Nectin-4-specific CAR T cells
Molecular Therapy20252 citations29 referencesContributes 0.038
Spectral Flow Cytometry: The Current State and Future of the Technology
International Journal of Molecular Sciences202513 citations98 referencesContributes 0.027
Under the Hood: Evidence-Based Review of Allogeneic Chimeric Antigen Receptor T Cells for Hematologic Malignancies
Transplantation and Cellular Therapy20257 citations82 referencesContributes 0.025

Authors (6)

Christian Flugel ORCID,Anson Cheung ORCID,Enzi Jiang,Alix Vaissié,Mohamed Abou‐El‐Enein ORCID

Live enrichment

PubMed:40315840 PMC:PMC12126796

National Institutes of Health National Cancer Institute

Grant: P30CA014089

hybridLicense: cc-by

publisherhttps://doi.org/10.1016/j.ymthe.2025.04.006

publisherhttps://api.elsevier.com/content/article/PII:S1525001625002801?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1525001625002801?httpAccept=text/plain

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12126796/pdf/main.pdf

Europe_PMChttps://europepmc.org/articles/PMC12126796

Fields of Study

HumansReceptors, Chimeric AntigenImmunotherapy, AdoptivePhenotypeImmunophenotypingBiomarkersCell DifferentiationFlow CytometryT-LymphocytesLymphocyte Activation

MeSH Terms

T-LymphocytesHumansImmunotherapy, AdoptiveFlow CytometryImmunophenotypingLymphocyte ActivationCell DifferentiationPhenotypeBiomarkersReceptors, Chimeric Antigen

Keywords

DifferentiationProliferationCytotoxicity assayExhaustionChimeric Antigen ReceptorPhenotypic CharacterizationImmunoprofilingSpectral Flow CytometryDeterminants Of ResponseCar T Cell TherapyCar T Cell Manufacturing