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Targeted degradation of the HPV oncoprotein E6 reduces tumor burden in cervical cancer

Molecular Therapy(2025)10.1016/j.ymthe.2025.08.033Source: DataRank Database

Targeted degradation of the HPV oncoprotein E6 reduces tumor burden in cervical cancer is a research paper published in Molecular Therapy (2025). On theSindex it has a DataRank of 0.312. It has been cited 7 times.

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0.312DataRank · unranked

Scored on demand from live citation data

Open Access7 citations

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pdb doi

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (15 grants)Impact (FWCI 5.91)OA: greenTopics (74)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.312

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

This paper's DataRank is currently driven only by its base citation score. Citation network data was not refreshed for this result.

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Authors (10)

Angelo Nicolaci,Kim C. Tran ORCID,Jameela Lokhandwala ORCID,Nina Obertopp ORCID,Jenet K Matlack ORCID

Live enrichment

PubMed:40873032 PMC:PMC12582245 OpenAlex:https://openalex.org/W4413682546

NIH National Institute of General Medical Sciences

Grant: K99/R00 GM154063

NIH National Institute of General Medical Sciences

Grant: R35 GM143004

National Institutes of Health National Cancer Institute

Grant: P30-CA076292

National Institutes of Health National Cancer Institute

Grant: U01 CA244100-01

American Cancer Society Inc

Grant: PF-22-041-01-ET

NIGMS NIH HHS

Grant: K99 GM154063

NCI NIH HHS

Grant: L70 CA284384

NCI NIH HHS

Grant: P30 CA076292

NCI NIH HHS

Grant: U01 CA244100

National Institutes of Health

Grant: 1U01CA244100-01

Predict radiation-induced shifts in patient-specific tumor immune ecosystem composition to harness immunological consequences of radiotherapy

National Institutes of Health

Grant: 5R35GM143004-04

Biophysical basis for enzyme mediated deglycation in protein repair

National Institutes of Health

Grant: 3P30CA076292-24S2

Moffitt Cancer Center Support Grant

H. Lee Moffitt Cancer Center and Research Institute

Centre for Incubation, Innovation, Research and Consultancy

National Institutes of Health

FWCI

5.91

Citation Percentile

1.0%

Citation Trend

2025

2026

greenLicense: cc-by-nc-nd

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12582245/

publisherhttps://api.elsevier.com/content/article/PII:S152500162500663X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S152500162500663X?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.ymthe.2025.08.033

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40873032

Fields of Study

Cervical Cancer and HPV ResearchMolecular Biology Techniques and Applications0301 basic medicine03 medical and health sciencesOncogene Proteins, ViralAnimalsFemaleUterine Cervical NeoplasmsHumansMiceRepressor ProteinsProteolysisTumor BurdenPapillomavirus InfectionsSingle-Domain AntibodiesCell Line, TumorDisease Models, AnimalHuman papillomavirus 16CD8-Positive T-LymphocytesVon Hippel-Lindau Tumor Suppressor ProteinVaccines, DNA

MeSH Terms

AnimalsUterine Cervical NeoplasmsDisease Models, AnimalFemaleHumansOncogene Proteins, ViralRepressor ProteinsCD8-Positive T-LymphocytesVaccines, DNAPapillomavirus InfectionsCell Line, TumorTumor BurdenMiceVon Hippel-Lindau Tumor Suppressor ProteinHuman papillomavirus 16ProteolysisSingle-Domain Antibodies

Keywords

Cervical cancerDegradation (telecommunications)Cancer researchCancerOncologyVirologyMedicineBiologyInternal medicineComputer scienceAntiviralHPVE6BiologicsNanobodyOncoproteinsBioprotacHuman papillomavirus 16Papillomavirus InfectionsUterine Cervical NeoplasmsOncogene Proteins, ViralSingle-Domain AntibodiesCD8-Positive T-LymphocytesArticleTumor BurdenRepressor ProteinsMiceDisease Models, AnimalVon Hippel-Lindau Tumor Suppressor ProteinCell Line, TumorProteolysisVaccines, DNAAnimalsHumansOriginal ArticleFemale

Sustainable Development Goals

SDG 0: Good health and well-being

Targeted degradation of the HPV oncoprotein E6 reduces tumor burden in cervical cancer

FAIR Checklist

DataRank Breakdown

Authors (10)

Funding (15 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)