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Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models

Regulatory Toxicology and Pharmacology(2025)10.1016/j.yrtph.2025.105906Source: DataRank Database

Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models is a research paper published in Regulatory Toxicology and Pharmacology (2025). On theSindex it has a DataRank of 0. It has been cited 10 times.

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0DataRank · unranked

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Open Access10 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 4.68)OA: greenTopics (39)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (10)

Hannah Xu,Xilin Li ORCID,Aisar Atrakchi,Timothy J. McGovern,Karen L Davis Bruno

Live enrichment

PubMed:40639678 OpenAlex:https://openalex.org/W4412363828

Center for Drug Evaluation and Research

Grant: 4189

Center for Drug Evaluation and Research

Grant: S00904

Intramural FDA HHS

Grant: FD999999

FWCI

4.68

Citation Percentile

1.0%

Citation Trend

2025

2026

greenLicense: https://www.elsevier.com/legal/tdmrep-license

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12442021/

publisherhttps://api.elsevier.com/content/article/PII:S0273230025001369?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0273230025001369?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.yrtph.2025.105906

Fields of Study

Carcinogens and Genotoxicity AssessmentSulfur Compounds in BiologyPolyamine Metabolism and ApplicationsMedicineEnvironmental ScienceChemistryHumansNitrosaminesDNA DamageMutagenicity TestsDrug ContaminationMutagensCell LineMicronucleus TestsComet AssaySpheroids, Cellular

MeSH Terms

Cell LineDNA DamageDrug ContaminationHumansMutagenicity TestsMutagensNitrosaminesMicronucleus TestsSpheroids, CellularComet Assay

Keywords

GenotoxicityChemistryNitrosaminePharmacologyCarcinogenBiochemistryToxicityMedicineOrganic chemistryBenchmark concentrationHepaRG cellsN-Nitrosamine impuritiesNitrosamine drug substance-related impurities (NDSRIs)

Sustainable Development Goals

SDG 0: Good health and well-being