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Geldanamycin inhibits trichostatin A-induced cell death and histone H4 hyperacetylation in COS-7 cells

Life Sciences(2002)10.1016/s0024-3205(01)01558-2Source: DataRank Database

Geldanamycin inhibits trichostatin A-induced cell death and histone H4 hyperacetylation in COS-7 cells is a research paper published in Life Sciences (2002). On theSindex it has a DataRank of 1.2. It has been cited 13 times, with 13 citing works in its 1-hop citation network.

N/A

1.2DataRank · unranked

Scored on demand from live citation data

13 citations · 13 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 0.44)OA: closedTopics (58)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 33%Citation Network 67%

Base Score Contribution

0.396

From this paper's citation signal

Citation Network Contribution

0.806

From 13 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 13 citers.

FK228 inhibits Hsp90 chaperone function in K562 cells via hyperacetylation of Hsp70
Biochemical and Biophysical Research Communications200754 citations33 referencesContributes 0.121
Discontinuous fragmentation of nuclear DNA during apoptosis revealed by discrete “sub‐G1” peaks on DNA content histograms
Cytometry Part A2007292 citations54 referencesContributes 0.105
Enhanced ubiquitinylation of heat shock protein 90 as a potential mechanism for mitotic cell death in cancer cells induced with hypericin.
PubMed200382 citations43 referencesContributes 0.103
HSP90 protects apoptotic cleavage of vimentin in geldanamycin-induced apoptosis
Molecular and Cellular Biochemistry200539 citations40 referencesContributes 0.092
Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells
International Journal of Oncology200672 citations49 referencesContributes 0.088

Authors (5)

Yin-Chang Liu,Shyh-Hwa Liu,Bor-Show Tzang,Wen-Chuan Lee,Hsiu-Chin Huang

Live enrichment

PubMed:12002521 OpenAlex:https://openalex.org/W1997432730

Ministry of Education

Grant: 89-B-7A04-1-4

Ministry of Education

Grant: 90-2313-B-059-003

Ministry of Education

Grant: NSC 88(89)-2313-B-059-019(019)-A20

National Science Council

FWCI

0.44

Citation Percentile

0.6%

Citation Trend

2017

closedLicense: https://www.elsevier.com/legal/tdmrep-license

publisherhttps://api.elsevier.com/content/article/PII:S0024320501015582?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0024320501015582?httpAccept=text/plain

journalhttps://doi.org/10.1016/s0024-3205(01)01558-2

repositoryhttps://pubmed.ncbi.nlm.nih.gov/12002521

Fields of Study

Heat shock proteins researchHistone Deacetylase Inhibitors ResearchSignaling Pathways in DiseaseAcetylationAnimalsAntibiotics, AntineoplasticApoptosisBenzoquinonesCOS CellsCell SurvivalDNA FragmentationDrug AntagonismEnzyme InhibitorsHSP70 Heat-Shock ProteinsHistone Deacetylase InhibitorsHistonesHydroxamic AcidsLactams, MacrocyclicQuinonesTransfection

MeSH Terms

AcetylationAnimalsAntibiotics, AntineoplasticCell SurvivalDrug AntagonismEnzyme InhibitorsHistonesHydroxamic AcidsQuinonesTransfectionBenzoquinonesApoptosisHSP70 Heat-Shock ProteinsCOS CellsLactams, MacrocyclicDNA FragmentationHistone Deacetylase Inhibitors

Keywords

Trichostatin AGeldanamycinDNA fragmentationMolecular biologyApoptosisFragmentation (computing)Cell cycleHistone deacetylase inhibitorChemistryHistone H4Hsp70Programmed cell deathHeat shock proteinHistoneHistone deacetylaseCell growthCell biologyHsp90BiologyDNABiochemistry

Sustainable Development Goals

SDG 0: Good health and well-being

Related Papers (2)

Geldanamycin as a Potential Anti-Cancer Agent: Its Molecular Target and Biochemical Activity

N/A

15.6DataRank · unranked

Investigational New Drugs(1999)

co-cited

10.1023/a:1006382320697

Molecular chaperones in cellular protein folding

N/A

17.5DataRank · unranked

Nature(1996)

co-cited

10.1038/381571a0

Geldanamycin inhibits trichostatin A-induced cell death and histone H4 hyperacetylation in COS-7 cells

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (5)

Funding (4 grants)

Impact

Open Access

Topics

Related Papers (2)