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Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling

Biochemistry(2023)10.1021/acs.biochem.3c00378Source: DataRank Database

Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling is a research paper published in Biochemistry (2023). On theSindex it has a DataRank of 0. It has been cited 5 times.

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Open Access5 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (2 grants)Impact (FWCI 0.38)OA: greenTopics (34)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Alexander D. Landgraf ORCID,Khuchtumur Bum‐Erdene ORCID,Giovanni González-Gutiérrez ORCID,Samy O. Meroueh ORCID,Robert J. Brenner

Live enrichment

PubMed:37938120 PMC:PMC10904212 OpenAlex:https://openalex.org/W4388489727

National Cancer Institute

Grant: R01CA264471

National Cancer Institute

Grant: R01CA197928

FWCI

0.38

Citation Percentile

0.5%

Citation Trend

2024

2025

greenLicense: https://doi.org/10.15223/policy-029

repositoryhttps://scholarworks.indianapolis.iu.edu/bitstreams/21855bc0-a3ff-4026-a823-d398399b5040/download

GREENhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10904212

repositoryhttps://scholarworks.indianapolis.iu.edu/bitstreams/21855bc0-a3ff-4026-a823-d398399b5040/download

publisherhttps://pubs.acs.org/doi/pdf/10.1021/acs.biochem.3c00378

repositoryhttps://hdl.handle.net/1805/41405

Fields of Study

Enzyme Structure and FunctionProtein Kinase Regulation and GTPase SignalingProtein Structure and DynamicsMedicineChemistryHumansProto-Oncogene Proteins p21(ras)Signal TransductionMolecular Dynamics SimulationProtein BindingAmino AcidsMutation

MeSH Terms

Amino AcidsHumansMutationProtein BindingSignal TransductionProto-Oncogene Proteins p21(ras)Molecular Dynamics Simulation

Keywords

KRASSmall moleculeDimerGTPaseDruggabilityAlanine scanningChemistryAmino acidMoleculeAlanineCrystallographyBiochemistryMutationMutagenesisGene

Sustainable Development Goals

SDG 0: Affordable and clean energy

Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling

FAIR Checklist

Authors (5)

Funding (2 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)