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Intracellular Pocket Conformations Determine Signaling Efficacy through the μ Opioid Receptor

Journal of Chemical Information and Modeling(2025)10.1021/acs.jcim.4c01437Source: DataRank Database

Intracellular Pocket Conformations Determine Signaling Efficacy through the μ Opioid Receptor is a research paper published in Journal of Chemical Information and Modeling (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Open Access2 citations

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Enrichment:Funding (7 grants)Impact (FWCI 0.77)OA: hybridTopics (49)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Joseph DePaolo-Boisvert,Stanley A. Nicholson,Barien Gad ORCID,David D. L. Minh ORCID,David A. Cooper

Live enrichment

PubMed:39824514 PMC:PMC11817682 OpenAlex:https://openalex.org/W4406517630

National Institute of General Medical Sciences

Grant: R01GM127712

National Science Foundation

Grant: 2138286

Track 2: Customized Multi-tier Assistance, Training, and Computational Help (MATCH) for End User ACCESS to CI

National Science Foundation

Grant: 2138307

Track 3: COre National Ecosystem for CyberinfrasTructure (CONECT)

National Science Foundation

Grant: 2138296

ACO: An Open CI Ecosystem to Advance Scientific Discovery (OpenCI)

National Science Foundation

Grant: 2137603

Track 4: Advanced CI Coordination Ecosystem: Monitoring and Measurement Services

National Institutes of Health

Grant: 5R01GM127712-02

Entropy for End-Point and FFT-Based Binding Free Energy Calculations

National Science Foundation

Grant: 2138259

Track 1: ACCESS Resource Allocations Marketplace and Platform Services (RAMPS)

FWCI

0.77

Citation Percentile

0.7%

Citation Trend

2026

hybridLicense: cc-by

journalhttps://pubs.acs.org/doi/pdf/10.1021/acs.jcim.4c01437

publisherhttps://pubs.acs.org/doi/pdf/10.1021/acs.jcim.4c01437

journalhttps://doi.org/10.1021/acs.jcim.4c01437

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39824514

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11817682/

Fields of Study

Receptor Mechanisms and SignalingNeuropeptides and Animal PhysiologyPharmacological Receptor Mechanisms and Effects0301 basic medicine03 medical and health sciencesReceptors, Opioid, muSignal TransductionLigandsProtein ConformationMachine LearningHumansIntracellular SpaceProtein BindingBinding SitesModels, Molecular

MeSH Terms

Machine Learningbeta-Arrestinsbeta-Arrestin 2Binding SitesHumansLigandsModels, MolecularProtein BindingProtein ConformationSignal TransductionReceptors, Opioid, muGTP-Binding ProteinsIntracellular Space

Keywords

IntracellularReceptorOpioidChemistryOpioid receptorPharmacologySignal transductionG protein-coupled receptorComputational biologyMedicineBiologyBiochemistryMachine LearningModels, MolecularBinding SitesProtein ConformationReceptors, Opioid, muIntracellular SpaceHumansLigandsProtein Binding

Intracellular Pocket Conformations Determine Signaling Efficacy through the μ Opioid Receptor

FAIR Checklist

Authors (5)

Funding (7 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)