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CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13

Journal of Chemical Information and Modeling(2025)10.1021/acs.jcim.5c00535Source: DataRank Database

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13 is a research paper published in Journal of Chemical Information and Modeling (2025). On theSindex it has a DataRank of 0.406. It has been cited 14 times.

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0.406DataRank · unranked

Scored on demand from live citation data

Open Access14 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (30 grants)Impact (FWCI 9.68)OA: greenTopics (62)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.406

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

This paper's DataRank is currently driven only by its base citation score. Citation network data was not refreshed for this result.

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Authors (110)

Madhushika Silva ORCID,Ayaz Ahmad ORCID,Oscar E. A. Arce ORCID,Roly J. Armstrong ORCID,Cheryl Arrowsmith

Live enrichment

PubMed:40539604 PMC:PMC12323591 OpenAlex:https://openalex.org/W4411493044

Irish Research Council

Grant: GOIPG/2021/954

National Institute of Allergy and Infectious Diseases

Grant: 1U19AI171110-01

QCRG Pandemic Response Program

National Institute of Allergy and Infectious Diseases

Grant: 1U19AI171292-01

RAPIDLY EMERGING ANTIVIRAL DRUG DEVELOPMENT INITIATIVE- AViDD CENTER (READDI-AC)

University of Edinburgh

Grant: 227243/Z/23/Z

Innovative Medicines Initiative

Grant: 875510

EUbOPEN: Enabling and Unlocking biology in the OPEN

National Institute of General Medical Sciences

Grant: R35GM140753

Research England

Grant: 131911

Fermentation of C1 feedstocks to 1,3-butanediol

Engineering and Physical Sciences Research Council

Grant: EP/S022791/1

EPSRC Centre for Doctoral Training in Molecular Sciences for Medicine

UK Research and Innovation

Grant: MR/T019654/1

Next generation atomistic modelling for medicinal chemistry and biology

Medical Research Council

Grant: MR/Y013131/1

The roles of a universally conserved DNA-and RNA-binding domain in controlling MRSA virulence and antibiotic resistance

The Slovenian Research and Innovation Agency

Grant: J7-50043

National Research Foundation of Korea

Grant: RS-2024-00440975

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Grant: 440363/2022-5

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul

Grant: 22/2551-0000385-0

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul

Grant: 22/2551-0000390-7

Structural Genomics Consortium

Grant: 1097737

Innovation, Science and Economic Development Canada

Grant: 816034

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Grant: 001

NIAID NIH HHS

Grant: R01 AI177498

NIAID NIH HHS

Grant: U19 AI171292

NIAID NIH HHS

Grant: U19 AI171110

Irish Research Council

Grant: unidentified

unidentified

Bill and Milica Beck PhD Endowment Fund

Diamond Light Source

Boehringer Ingelheim

McGill University

Ontario Institute for Cancer Research

Korea Institute of Science and Technology

European Federation of Pharmaceutical Industries and Associations

Kungliga Tekniska Högskolan

FWCI

9.68

Citation Percentile

1.0%

Influential Citations

Citation Trend

2025

2026

greenLicense: cc-by

repositoryhttps://www.research.ed.ac.uk/files/514907822/CACHE2_Manuscript_File_May25.docx_2_.pdf

GREENhttps://vbn.aau.dk/ws/files/812607218/cache-challenge-2-targeting-the-rna-site-of-the-sars-co-v-2-helicase-nsp13.pdf

repositoryhttps://www.research.ed.ac.uk/files/514907822/CACHE2_Manuscript_File_May25.docx_2_.pdf

publisherhttps://pubs.acs.org/doi/pdf/10.1021/acs.jcim.5c00535

repositoryhttps://www.research.ed.ac.uk/en/publications/39820ef6-f2e8-4770-9b71-ae471a787980

Fields of Study

Computational Drug Discovery MethodsSARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approachesMedicineComputer ScienceChemistry0206 medical engineering02 engineering and technologyViral Nonstructural ProteinsCoronavirus RNA-Dependent RNA PolymeraseRNA HelicasesBinding SitesLigandsDeep LearningRNA

MeSH Terms

Machine LearningDeep LearningCOVID-19SARS-CoV-2Coronavirus RNA-Dependent RNA PolymeraseCOVID-19 Drug TreatmentAntiviral AgentsBinding SitesHumansLigandsMethyltransferasesProtein BindingRNARNA, ViralViral Nonstructural ProteinsRNA HelicasesDrug DiscoveryMolecular Docking Simulation

Keywords

HelicaseComputational biologyDrug discoveryVirtual screeningDocking (animal)Computer scienceChemistrySurface plasmon resonanceCacheRNABiologyBiochemistryNanotechnologyNanoparticleMaterials scienceMedicineCoronavirus RNA-Dependent RNA PolymeraseBinding SitesMoleculesViral Nonstructural ProteinsLigandsScreening assaysArticleAssaysDeep LearningdockingGeneticsVirtual screening; CACHE; dockingRNA Helicases

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13

FAIR Checklist

DataRank Breakdown

Authors (110)

Funding (30 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)