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Engineering Mechanical Microenvironments: Integration of Substrate and Flow Mechanics Reveals the Impact on the Endothelial Glycocalyx

ACS Biomaterials Science & Engineering(2025)10.1021/acsbiomaterials.4c02401Source: DataRank Database

Engineering Mechanical Microenvironments: Integration of Substrate and Flow Mechanics Reveals the Impact on the Endothelial Glycocalyx is a research paper published in ACS Biomaterials Science & Engineering (2025). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Open Access4 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (6 grants)Impact (FWCI 4.00)OA: hybridTopics (50)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Yu Chen ORCID,Emily R. Tressler,Lucas McCauley,Nicholas R. O’Hare ORCID,Chinedu C. Okorafor

Live enrichment

PubMed:40434411 PMC:PMC12152830 OpenAlex:https://openalex.org/W4410818114

National Institutes of Health

Grant: R01 EB027705

National Science Foundation

Grant: CMMI 1846962

National Science Foundation

Grant: DMR 1847843

National Institutes of Health

Grant: 5R01EB027705-03

Overcoming vaccine-associated hypoxia with advanced biomaterials to enhance cancer immunotherapy

National Science Foundation

Grant: 1847843

CAREER: Modulating Local Tumor Hypoxia using Cryogel Scaffolds to Regulate Dendritic Cell Function and Activity

National Science Foundation

Grant: 1846962

CAREER: EMBRACE STEM (Endothelial MechanoBiology Research And multiCultural Education in STEM)

FWCI

4.00

Citation Percentile

0.9%

Citation Trend

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://doi.org/10.1021/acsbiomaterials.4c02401

publisherhttps://doi.org/10.1021/acsbiomaterials.4c02401

publisherhttps://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.4c02401

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40434411

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12152830

Fields of Study

Trauma, Hemostasis, Coagulopathy, ResuscitationBlood properties and coagulationHippo pathway signaling and YAP/TAZ0301 basic medicine03 medical and health sciences

MeSH Terms

YAP-Signaling ProteinsCells, CulturedGelatinHeparitin SulfateHeparan SulfateHumansHyaluronic AcidMethacrylatesStress, MechanicalHyaluronan ReceptorsGlycocalyxMechanotransduction, CellularSyndecan-1Cellular MicroenvironmentHuman Umbilical Vein Endothelial Cells

Keywords

GlycocalyxSubstrate (aquarium)Materials scienceFlow (mathematics)MechanicsNanotechnologyGeologyPhysicsCell biologyBiologyAtherosclerosisHypertensionShear stressStiffnessMechanotransductionEndothelial GlycocalyxYAP-Signaling ProteinsMechanotransduction, CellularArticleHeparan SulfateHyaluronan ReceptorsCellular MicroenvironmentHuman Umbilical Vein Endothelial CellsHumansGelatinMethacrylatesStress, MechanicalSyndecan-1Hyaluronic AcidCells, Cultured

Sustainable Development Goals

SDG 0: Zero hunger

Engineering Mechanical Microenvironments: Integration of Substrate and Flow Mechanics Reveals the Impact on the Endothelial Glycocalyx

FAIR Checklist

Authors (8)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)