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Receptor–Ligand Kinetics Influence the Mechanism of Action of Covalently Linked TLR Ligands

ACS Chemical Biology(2021)10.1021/acschembio.0c00924Source: DataRank Database

Receptor–Ligand Kinetics Influence the Mechanism of Action of Covalently Linked TLR Ligands is a research paper published in ACS Chemical Biology (2021). On theSindex it has a DataRank of 0. It has been cited 7 times.

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Open Access7 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (3 grants)Impact (FWCI 0.44)OA: greenTopics (91)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Jainu Ajit ORCID,Alexander Galluppi ORCID,Saikat Manna ORCID,William J. Howitz ORCID,Sophia Tang ORCID

Live enrichment

PubMed:33523635 PMC:PMC8936418 OpenAlex:https://openalex.org/W3127674307

National Institutes of Health

Grant: 7U01AI124286-03

Determining the Mechanism of Activation of Linked Agonists Synergies

NIAID NIH HHS

Grant: U01 AI124286

National Institutes of Health

Grant: 5U01AI124286-05

Determining the Mechanism of Activation of Linked Agonists Synergies

FWCI

0.44

Citation Percentile

0.5%

Influential Citations

Citation Trend

2021

2023

2024

2025

greenLicense: STM Policy #29

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8936418

GREENhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936418

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8936418

publisherhttps://pubs.acs.org/doi/pdf/10.1021/acschembio.0c00924

journalhttps://doi.org/10.1021/acschembio.0c00924

Fields of Study

Immune Response and InflammationNF-κB Signaling PathwaysImmunotherapy and Immune ResponsesMedicineChemistry0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsCytokinesDose-Response Relationship, DrugHeterocyclic Compounds, 3-RingKineticsLigandsLipopeptidesMiceNF-kappa BOligonucleotidesRAW 264.7 CellsToll-Like ReceptorsTumor Necrosis Factor-alpha

MeSH Terms

RAW 264.7 CellsAnimalsDose-Response Relationship, DrugHeterocyclic Compounds, 3-RingKineticsLigandsOligonucleotidesTumor Necrosis Factor-alphaCytokinesNF-kappa BToll-Like ReceptorsMiceLipopeptides

Keywords

AgonistReceptorChemistryLigand (biochemistry)KineticsTumor necrosis factor alphaCell biologyCytokineToll-like receptorImmune systemBiophysicsReceptor–ligand kineticsT-cell receptorMechanism of actionIn vitroEnhancerBiochemistryBiologyT cellImmunologyInnate immune systemGene expressionGeneactivation kineticsChemical Sciences not elsewhere classifiedcell-based assaysreceptor locationsOligonucleotidesTLR LigandsLigandsNF -κBTLR agonistsagonist influenceLipopeptidesMiceAnimalsMolecular BiologyPharmacologyB cellsDose-Response Relationship, DrugTLR systemsTumor Necrosis Factor-alphaToll-Like ReceptorsNF-kappa Bligand specificityfactor kappa-light-chain-enhancertime-resolved TNF -αInfectious DiseasesRAW 264.7 Cellsvaccine designMedicineCytokinescytokine expression profilesTumor Necrosis FactorHeterocyclic Compounds, 3-RingBiotechnologyBiological Sciences not elsewhere classified

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being