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Chemical and Genetic Validation of an Essential Calcium Entry Channel of Trypanosoma brucei as a Therapeutic Target

ACS Infectious Diseases(2025)10.1021/acsinfecdis.5c00329Source: DataRank Database

Chemical and Genetic Validation of an Essential Calcium Entry Channel of Trypanosoma brucei as a Therapeutic Target is a research paper published in ACS Infectious Diseases (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Open Access2 citations

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Enrichment:Funding (8 grants)Impact (FWCI 1.36)OA: hybridTopics (49)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

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Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Harmanpreet Singh ORCID,Priti Chatterjee ORCID,Rohit Kumar Varshnaya ORCID,Donald Hamelberg ORCID,Binghe Wang ORCID

Live enrichment

PubMed:40462260 PMC:PMC12172032 OpenAlex:https://openalex.org/W4411038210

Division of Microbiology and Infectious Diseases

Grant: AI156096

National Institute of General Medical Sciences

Grant: R35GM153718

NIAID NIH HHS

Grant: R21 AI156096

National Institutes of Health

Grant: 5R35GM153718-02

Developing computational tools to complement experiments in understanding biomolecular function from conformational ensembles

National Institutes of Health

Grant: 5R21AI156096-02

Piezo channels and calcium signaling in Trypanosoma cruzi

Georgia State University

Georgia Research Alliance

Frank Hannah Chair

FWCI

1.36

Citation Percentile

0.8%

Citation Trend

2025

2026

hybridLicense: cc-by

journalhttps://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.5c00329?ref=article_openPDF

publisherhttps://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.5c00329?ref=article_openPDF

publisherhttps://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.5c00329

journalhttps://doi.org/10.1021/acsinfecdis.5c00329

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40462260

Fields of Study

Trypanosoma species research and implicationsCalcium signaling and nucleotide metabolismResearch on Leishmaniasis Studies0303 health sciences03 medical and health sciencesTrypanosoma brucei bruceiHumansCalcium ChannelsHEK293 CellsTrypanocidal AgentsProtozoan ProteinsAnimalsCalcium Channel BlockersCalciumMolecular Docking SimulationTrypanosomiasis, African

MeSH Terms

AnimalsCalciumCalcium Channel BlockersHumansTrypanocidal AgentsTrypanosoma brucei bruceiTrypanosomiasis, AfricanCalcium ChannelsProtozoan ProteinsHEK293 CellsMolecular Docking Simulation

Keywords

Trypanosoma bruceiCalciumCalcium channelBiologyComputational biologyChemistryBiochemistryGeneTarget ValidationDocking AnalysisYeast ComplementationTrypanosoma brucei bruceiProtozoan ProteinsCalcium Channel BlockersTrypanocidal AgentsArticleMolecular Docking SimulationHEK293 CellsTrypanosomiasis, AfricanHumansAnimalsCalcium Channels

Sustainable Development Goals

SDG 0: Zero hunger

Chemical and Genetic Validation of an Essential Calcium Entry Channel of Trypanosoma brucei as a Therapeutic Target

FAIR Checklist

Authors (7)

Funding (8 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)