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A First-in-Class Chemical-Induced Proximity System Achieves Dose-Dependent Control of Tumor Protein P53 Gene Activation in Preclinical Models of Gastric Cancer

ACS Pharmacology & Translational Science(2025)10.1021/acsptsci.5c00402Source: DataRank Database

A First-in-Class Chemical-Induced Proximity System Achieves Dose-Dependent Control of Tumor Protein P53 Gene Activation in Preclinical Models of Gastric Cancer is a research paper published in ACS Pharmacology & Translational Science (2025). On theSindex it has a DataRank of 0.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (6 grants)Impact (FWCI 0.00)OA: hybridTopics (18)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (17)

Ryan M. Kemper ORCID,Anna M. Chiarella ORCID,Stephany Gonzalez Tineo,Michael C. Carroll ORCID,Surya Tripathi

Live enrichment

PubMed:41098562 OpenAlex:https://openalex.org/W4414051197

American Cancer Society

Grant: RSG-21-091-01

National Institute of General Medical Sciences

Grant: R35GM148365

National Institute of General Medical Sciences

Grant: R41GM146326

NCI NIH HHS

Grant: P30 CA016086

NIH HHS

Grant: S10 OD025132

NIH HHS

Grant: S10 OD028504

FWCI

0.00

Citation Percentile

0.1%

hybridLicense: cc-by

journalhttps://pubs.acs.org/doi/pdf/10.1021/acsptsci.5c00402?ref=article_openPDF

publisherhttps://pubs.acs.org/doi/pdf/10.1021/acsptsci.5c00402?ref=article_openPDF

publisherhttps://pubs.acs.org/doi/pdf/10.1021/acsptsci.5c00402

journalhttps://doi.org/10.1021/acsptsci.5c00402

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41098562

Fields of Study

Click Chemistry and ApplicationsRNA Interference and Gene DeliveryCancer-related Molecular Pathways

Keywords

EpigenomeEpigeneticsCancerCancer cellGeneGene expressionTumor suppressor geneCell cycleTumor cellsCRISPRTP53apoptosiscell cycle arrestchemical-induced proximitygene therapy