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Overcoming Leak Sensitivity in CRISPRi Circuits Using Antisense RNA Sequestration and Regulatory Feedback

ACS Synthetic Biology(2022)10.1021/acssynbio.2c00155Source: DataRank Database

Overcoming Leak Sensitivity in CRISPRi Circuits Using Antisense RNA Sequestration and Regulatory Feedback is a research paper published in ACS Synthetic Biology (2022). On theSindex it has a DataRank of 0. It has been cited 10 times.

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Open Access10 citations

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Enrichment:Funding (4 grants)Impact (FWCI 0.79)OA: hybridTopics (41)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (3)

Louis B. G. Cortes ORCID,Guillaume Lambert ORCID,David A. Specht ORCID

Live enrichment

PubMed:36017994 PMC:PMC9486968 OpenAlex:https://openalex.org/W4293115787

National Institutes of Health

Grant: 1R35 GM133759

NIGMS NIH HHS

Grant: R35 GM133759

National Science Foundation

Grant: 2025233

NNCI: Cornell NanoScale Science and Technology Facility (CNF)

National Institutes of Health

Grant: 5R35GM133759-04

Metabolic Control of Persistence in Individual Bacteria

FWCI

0.79

Citation Percentile

0.7%

Citation Trend

2022

2023

2024

2025

hybridLicense: cc-by-nc-nd

journalhttps://doi.org/10.1021/acssynbio.2c00155

publisherhttps://doi.org/10.1021/acssynbio.2c00155

publisherhttps://pubs.acs.org/doi/pdf/10.1021/acssynbio.2c00155

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36017994

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9486968

Fields of Study

CRISPR and Genetic EngineeringGene Regulatory Network AnalysisRNA and protein synthesis mechanisms0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

RNA, Guide, CRISPR-Cas SystemsDNAEscherichia coliFeedbackRNA, AntisenseRNA, Guide, KinetoplastidaClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas Systems

Keywords

Synthetic biologyBiologyCRISPRGuide RNACRISPR interferenceComputational biologyElectronic circuitTrans-activating crRNACell biologyCas9GeneticsGeneEngineeringElectrical engineeringAntisenseSequestrationCircuitSingle-cellInverterCrispriEscherichia coliClustered Regularly Interspaced Short Palindromic RepeatsRNA, AntisenseDNACRISPR-Cas SystemsRNA, Guide, CRISPR-Cas SystemsFeedback

Sustainable Development Goals

SDG 0: Peace, Justice and strong institutions

Overcoming Leak Sensitivity in CRISPRi Circuits Using Antisense RNA Sequestration and Regulatory Feedback

FAIR Checklist

Authors (3)

Funding (4 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)