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Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase

Journal of the American Chemical Society(2021)10.1021/jacs.1c03572Source: DataRank Database

Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase is a research paper published in Journal of the American Chemical Society (2021). On theSindex it has a DataRank of 0. It has been cited 16 times.

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Open Access16 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (6 grants)Impact (FWCI 1.36)OA: greenTopics (31)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (10)

Peter F. Doubleday ORCID,Arseniy Butrin,Pathum M. Weerawarna ORCID,Rafael D. Melani ORCID,Daniel S. Catlin

Live enrichment

PubMed:34014654 PMC:PMC8369387 OpenAlex:https://openalex.org/W3161790388

National Institute on Drug Abuse

Grant: P30 DA018310

National Institute on Drug Abuse

Grant: R01 DA030604

National Institute on Drug Abuse

Grant: S10 OD025194

National Science Foundation

Grant: ACI-1548562

National Science Foundation

Grant: NNCI-1542205

NCI NIH HHS

Grant: R01 CA260250

FWCI

1.36

Citation Percentile

0.8%

Citation Trend

2021

2022

2023

2024

2025

2026

greenLicense: https://doi.org/10.15223/policy-029

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8369387

publisherhttps://pubs.acs.org/doi/pdf/10.1021/jacs.1c03572

journalhttps://doi.org/10.1021/jacs.1c03572

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34014654

Fields of Study

Amino Acid Enzymes and MetabolismMass Spectrometry Techniques and ApplicationsEnzyme Structure and FunctionEnzyme InhibitorsHumansKineticsMass SpectrometryModels, MolecularMolecular StructureOrnithine-Oxo-Acid Transaminase

MeSH Terms

Enzyme InhibitorsHumansKineticsModels, MolecularOrnithine-Oxo-Acid TransaminaseMass SpectrometryMolecular Structure

Keywords

ChemistryActive siteStereochemistryCovalent bondNucleophileEnzymeOrnithine aminotransferaseEnzyme kineticsOrnithineBiochemistryAmino acidOrganic chemistryCatalysisArginine

Sustainable Development Goals

SDG 0: Clean water and sanitation

Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase

FAIR Checklist

Authors (10)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)