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Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids

Journal of the American Chemical Society(2022)10.1021/jacs.2c02323Source: DataRank Database

Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids is a research paper published in Journal of the American Chemical Society (2022). On theSindex it has a DataRank of 0.360. It has been cited 10 times.

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0.360DataRank · unranked

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Open Access10 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (20 grants)Impact (FWCI 0.78)OA: hybridTopics (54)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

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Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.360

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (10)

Charlene H. Kim ORCID,Scott C. Virgil ORCID,Hailey J. Knox ORCID,Jonathan S. Marvin ORCID,Aaron L. Nichols ORCID

Live enrichment

PubMed:35446570 PMC:PMC9121368 OpenAlex:https://openalex.org/W4226270664

National Institute of Neurological Disorders and Stroke

Grant: T32NS105595

Tobacco-Related Disease Research Program

Grant: 27FT-0022

Tobacco-Related Disease Research Program

Grant: 27IP-0057

Tobacco-Related Disease Research Program

Grant: T29IR0455

National Institute on Drug Abuse

Grant: DA043829

National Institute on Drug Abuse

Grant: DA049140

National Institute of General Medical Sciences

Grant: GM-123582

National Institute of General Medical Sciences

Grant: GM-7616

NIGMS NIH HHS

Grant: T32 GM007616

NIGMS NIH HHS

Grant: R01 GM123582

NIH HHS

Grant: S10 OD020013

NIDA NIH HHS

Grant: R21 DA043829

NIH HHS

Grant: S10 OD010788

NIDA NIH HHS

Grant: R21 DA049140

National Institutes of Health

Grant: 5T32GM007616-23

PREDOCTORAL TRAINING IN BIOLOGY AND CHEMISTRY

National Institutes of Health

Grant: 5R01GM123582-02

Fluorescent biosensors for subcellular pharmacokinetics

National Institutes of Health

Grant: 1R21DA043829-01

Nicotine Inside Neurons

National Institutes of Health

Grant: 5T32NS105595-02

Predoctoral Training in Quantitative Neuroscience

National Institutes of Health

Grant: 5R21DA049140-02

Opioids inside Organelles

Howard Hughes Medical Institute

FWCI

0.78

Citation Percentile

0.7%

Citation Trend

2022

2023

2024

2025

hybridLicense: cc-by-nc-nd

journalhttps://pubs.acs.org/doi/pdf/10.1021/jacs.2c02323

HYBRIDhttps://pubs.acs.org/doi/pdf/10.1021/jacs.2c02323

publisherhttps://pubs.acs.org/doi/pdf/10.1021/jacs.2c02323

journalhttps://doi.org/10.1021/jacs.2c02323

repositoryhttps://pubmed.ncbi.nlm.nih.gov/35446570

Fields of Study

Receptor Mechanisms and SignalingLipid Membrane Structure and BehaviorIon channel regulation and functionBiologyMedicineChemistry0301 basic medicine03 medical and health sciencesAnimalsMammalsMethadoneMiceMutationNicotinic AgonistsOrganellesPeriplasmic Binding Proteins

MeSH Terms

AnimalsMammalsMethadoneMutationOrganellesNicotinic AgonistsPeriplasmic Binding ProteinsMice

Keywords

ChemistryPeriplasmic spaceGolgi apparatusBiochemistryCell biologyBiophysicsGeneEndoplasmic reticulumMammalsOrganelles570Sensors610General Chemistry540FluorescenceOpioidsSubstance MisuseMiceEngineeringChemical sciencesPeriplasmic Binding ProteinsMutationGeneticsPharmaceuticalsAnimalsFluorescence, Genetics, Sensors, Pharmaceuticals, BiotechnologyNicotinic AgonistsMethadoneBiotechnology

Sustainable Development Goals

SDG 0: Clean water and sanitation

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Evaluating Highly Selective Nicotinic Receptor Agonists and Antagonists

10.17920/g9z243University of California Office of the President