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Engineering C–C Bond Cleavage Activity into a P450 Monooxygenase Enzyme

Journal of the American Chemical Society(2023)10.1021/jacs.3c01456Source: DataRank Database

Engineering C–C Bond Cleavage Activity into a P450 Monooxygenase Enzyme is a research paper published in Journal of the American Chemical Society (2023). On theSindex it has a DataRank of 0. It has been cited 29 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access29 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 5.80)OA: greenTopics (37)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Joel H. Z. Lee ORCID,Mark A. McLean ORCID,Rebecca R. Chao,Isobella S. J. Stone ORCID,Tara L. Pukala ORCID

Live enrichment

PubMed:37042073 OpenAlex:https://openalex.org/W4365136290

Australian Research Council

Grant: DP140103229

Discovery Projects - Grant ID: DP140103229

Australian Research Council

Grant: FT140100355

ARC Future Fellowships - Grant ID: FT140100355

National Institute of General Medical Sciences

Grant: GM118145

FWCI

5.80

Citation Percentile

1.0%

Citation Trend

2023

2024

2025

2026

greenLicense: STM Policy #29

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10795798/pdf/nihms-1958979.pdf

publisherhttps://pubs.acs.org/doi/pdf/10.1021/jacs.3c01456

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/10795798

journalhttps://doi.org/10.1021/jacs.3c01456

Fields of Study

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsComputational Drug Discovery Methods01 natural sciences0104 chemical sciences

MeSH Terms

CatalysisHumansLyasesCatalytic DomainMolecular Dynamics Simulation

Keywords

ChemistryLyaseBond cleavageStereochemistryCYP17A1Catalytic cycleMonooxygenaseActive siteBenzoic acidKetoneKinetic isotope effectCatalysisEnzymeCytochrome P450Organic chemistry1303 Biochemistry1503 CatalysisLyases1505 Colloid and Surface ChemistryGeneral ChemistryMolecular Dynamics Simulation5401600 ChemistryBiochemistryColloid and Surface ChemistryCatalytic DomainHumans