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Optimized Substrate Positioning Enables Switches in the C–H Cleavage Site and Reaction Outcome in the Hydroxylation–Epoxidation Sequence Catalyzed by Hyoscyamine 6β-Hydroxylase

Journal of the American Chemical Society(2024)10.1021/jacs.4c04406Source: DataRank Database

Optimized Substrate Positioning Enables Switches in the C–H Cleavage Site and Reaction Outcome in the Hydroxylation–Epoxidation Sequence Catalyzed by Hyoscyamine 6β-Hydroxylase is a research paper published in Journal of the American Chemical Society (2024). On theSindex it has a DataRank of 0.510. It has been cited 29 times.

N/A

0.510DataRank · unranked

Scored on demand from live citation data

Open Access29 citations

Cite:

Linked data & code

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (15 grants)Impact (FWCI 3.70)OA: greenTopics (34)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.510

From this paper's citation signal

Citation Network Contribution

0

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Authors (18)

Ryan J. Martinie ORCID,Richiro Ushimaru ORCID,Christopher J. Pollock ORCID,Debangsu Sil ORCID,Aaron Li ORCID

Live enrichment

PubMed:39172701 PMC:PMC11374477 OpenAlex:https://openalex.org/W4401733438

National Institute of General Medical Sciences

Grant: F32GM113389

National Institute of General Medical Sciences

Grant: GM113106

National Institute of General Medical Sciences

Grant: GM118812

National Institute of General Medical Sciences

Grant: GM119707

National Institute of General Medical Sciences

Grant: GM127079

National Institute of General Medical Sciences

Grant: GM141284

NIGMS NIH HHS

Grant: R01 GM118812

NIGMS NIH HHS

Grant: R01 GM141284

NIGMS NIH HHS

Grant: R01 GM113106

NIGMS NIH HHS

Grant: R35 GM119707

NIGMS NIH HHS

Grant: R35 GM127079

National Institutes of Health

Grant: 3F32GM113389-02S1

Mechanistic Determination of the Non-heme Iron Enzyme Hyoscyamine-6-hydroxylase

National Institutes of Health

Grant: 5R01GM118812-04

Mechanisms and Reprogramming of Iron/2-Oxoglutarate Desaturases and Oxacyclases

National Institutes of Health

Grant: 5R01GM113106-03

Mechanisms of oxacycle- and olefin-installing iron/2-(oxo)glutarate oxygenases

National Science Foundation

FWCI

3.70

Citation Percentile

0.9%

Citation Trend

2024

2025

2026

greenLicense: CC BY NC ND

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11374477/pdf/nihms-2012852.pdf

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11374477/pdf/nihms-2012852.pdf

publisherhttps://pubs.acs.org/doi/pdf/10.1021/jacs.4c04406

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11374477

journalhttps://doi.org/10.1021/jacs.4c04406

Fields of Study

Metal-Catalyzed Oxygenation MechanismsMicrobial metabolism and enzyme functionPorphyrin Metabolism and DisordersMedicineChemistry01 natural sciences0104 chemical sciencesHydroxylationMixed Function OxygenasesSubstrate SpecificityBiocatalysisEpoxy Compounds

MeSH Terms

Epoxy CompoundsMixed Function OxygenasesHydroxylationSubstrate SpecificityBiocatalysis

Keywords

ChemistryHydroxylationStereochemistryBond cleavageCleavage (geology)CatalysisActive siteSubstrate (aquarium)OxygenEnzymePhotochemistryBiochemistryOrganic chemistryBiocatalysisEpoxy CompoundsMixed Function OxygenasesSubstrate Specificity

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