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Structural Heterogeneity of Proteoform-Ligand Complexes in Adenosine Monophosphate-Activated Protein Kinase Uncovered by Integrated Top-Down Mass Spectrometry

Journal of the American Chemical Society(2025)10.1021/jacs.5c06950Source: DataRank Database

Structural Heterogeneity of Proteoform-Ligand Complexes in Adenosine Monophosphate-Activated Protein Kinase Uncovered by Integrated Top-Down Mass Spectrometry is a research paper published in Journal of the American Chemical Society (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Open Access2 citations

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Enrichment:Funding (10 grants)Impact (FWCI 0.79)OA: hybridTopics (38)IDs (PubMed, PMC, OpenAlex)Annotations (2)

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Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (13)

Boris Krichel ORCID,Liam J. Bandura,Emily A. Chapman ORCID,Holden T. Rogers ORCID,Matthew S. Fischer ORCID

Live enrichment

PubMed:40811720 PMC:PMC12367072 OpenAlex:https://openalex.org/W4413139094

Damon Runyon Cancer Research Foundation

Grant: DRG-2526-24

European Commission

Grant: 101068151

H2020 Marie Sklodowska-Curie Actions

Grant: PF-01

National Institutes of Health

Grant: R01 GM117058

National Institutes of Health

Grant: R01 HL109810

National Institutes of Health

Grant: S10 OD018475

National Institutes of Health

Grant: T32GM152341

National Institutes of Health

Grant: T32HL007936

H2020 European Research Council

Grant: StG-2017 759661

European Research Council

Grant: 759661

Sampling Protein cOmplex Conformational Space with native top down Mass Spectrometry

FWCI

0.79

Citation Percentile

0.7%

Citation Trend

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1021/jacs.5c06950

publisherhttps://doi.org/10.1021/jacs.5c06950

publisherhttps://pubs.acs.org/doi/pdf/10.1021/jacs.5c06950

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40811720

repositoryhttps://bib-pubdb1.desy.de/record/637345

Fields of Study

Metabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase SignalingEnzyme Structure and Function0303 health sciences03 medical and health sciences

MeSH Terms

Adenosine MonophosphateHumansLigandsModels, MolecularPhosphorylationProtein Processing, Post-TranslationalMass SpectrometryAMP-Activated Protein Kinases

Keywords

Heterotrimeric G proteinChemistryAMPKProtein kinase APhosphorylationProtein subunitBiochemistryAdenosineCell biologyKinaseLigand (biochemistry)Signal transductionG proteinBiologyReceptorModels, Molecularinfo:eu-repo/classification/ddc/540HumansAMP-Activated Protein KinasesLigands540Protein Processing, Post-TranslationalArticleMass SpectrometryAdenosine Monophosphate

Structural Heterogeneity of Proteoform-Ligand Complexes in Adenosine Monophosphate-Activated Protein Kinase Uncovered by Integrated Top-Down Mass Spectrometry

FAIR Checklist

Authors (13)

Funding (10 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)