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Development of FBXO22 Degraders and the Recruitment Ligand 2-Pyridinecarboxyaldehyde (2-PCA)

Journal of the American Chemical Society(2025)10.1021/jacs.5c14141Source: DataRank Database

Development of FBXO22 Degraders and the Recruitment Ligand 2-Pyridinecarboxyaldehyde (2-PCA) is a research paper published in Journal of the American Chemical Society (2025). On theSindex it has a DataRank of 0. It has been cited 7 times.

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7 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (12 grants)Impact (FWCI 3.45)OA: closedTopics (36)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Zhe Zhuang ORCID,Woong Sub Byun ORCID,Zuzanna Kozicka ORCID,Kheewoong Baek ORCID,Jianing Zhong

Live enrichment

PubMed:41292500 OpenAlex:https://openalex.org/W4416686633

National Cancer Institute

Grant: P01CA066996

National Cancer Institute

Grant: R01CA214608

National Cancer Institute

Grant: R01CA218278

National Cancer Institute

Grant: R01CA262188

Damon Runyon Cancer Research Foundation

Grant: DRG-2514-24

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

Grant: P500PB_214385

National Research Foundation of Korea

Grant: RS-2024-00410290

National Institutes of Health

Grant: 1S10OD028697-01

500 MHz NMR Spectrometer System with High Sensitivity Cryoprobe and Automated Sample Changer for Biochemical Research

Swiss National Science Foundation

Grant: 214385

Elucidation of protein degradation machinery for transcription factor dependencies in acute myeloid leukemia

Stanford Chemical and Systems Biology

Howard Hughes Medical Institute

Stanford Cancer Institute

FWCI

3.45

Citation Percentile

0.9%

Citation Trend

2026

closedLicense: STM Policy #29

publisherhttps://pubs.acs.org/doi/pdf/10.1021/jacs.5c14141

journalhttps://doi.org/10.1021/jacs.5c14141

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41292500

Fields of Study

Protein Degradation and InhibitorsUbiquitin and proteasome pathwaysClick Chemistry and ApplicationsHumansLigandsF-Box ProteinsUbiquitin-Protein LigasesProteolysisPyridinesMolecular StructureReceptors, Cytoplasmic and Nuclear

MeSH Terms

HumansLigandsPyridinesMolecular StructureReceptors, Cytoplasmic and NuclearUbiquitin-Protein LigasesF-Box ProteinsProteolysis

Keywords

DegronUbiquitin ligaseSmall moleculeChemical biologyUbiquitinCysteineLigand (biochemistry)DNA ligaseUbiquitin-Protein LigasesProtein degradationMolecular StructurePyridinesF-Box ProteinsProteolysisHumansReceptors, Cytoplasmic and NuclearLigands

Development of FBXO22 Degraders and the Recruitment Ligand 2-Pyridinecarboxyaldehyde (2-PCA)

FAIR Checklist

Authors (12)

Funding (12 grants)

Impact

Open Access

Topics