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Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

Nature(2017)10.1038/nature24028Source: DataRank Database

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours is a research paper published in Nature (2017). On theSindex it has a DataRank of 10.8. It has been cited 844 times, with 200 citing works in its 1-hop citation network.

N/A

10.8DataRank · unranked

Scored on demand from live citation data

844 citations · 200 citing works in its network

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Linked data & code

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 24.13)OA: greenTopics (63)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 9%Citation Network 91%

Base Score Contribution

1.0

From this paper's citation signal

Citation Network Contribution

9.8

From 200 citing papers with measurable signal

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Authors (39)

Clarissa G. Jakob,Rohinton P. Edalji,Wei Qiu ORCID,Debra Montgomery,Enrico L. Digiammarino

Live enrichment

PubMed:28953875 PMC:PMC6050590 OpenAlex:https://openalex.org/W2758743773

Novo Nordisk Fonden

Grant: NNF14OC0008541

Novo Nordisk Foundation Center for Protein Research

Grant: PI Chunaram Choudhary

NIGMS NIH HHS

Grant: R37 GM062437

FWCI

24.13

Citation Percentile

1.0%

Citation Trend

2017

2018

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2020

2021

2022

2023

2024

2025

2026

greenLicense: http://www.springer.com/tdm

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/6050590

publisherhttp://www.nature.com/articles/nature24028.pdf

publisherhttp://www.nature.com/articles/nature24028

publisherhttp://www.nature.com/doifinder/10.1038/nature24028

Fields of Study

Ubiquitin and proteasome pathwaysProtein Degradation and InhibitorsCancer-related gene regulationAcetyl Coenzyme AAnimalsAntineoplastic AgentsBinding, CompetitiveBiocatalysisCatalytic DomainCell Line, TumorCell LineageCell ProliferationCrystallography, X-RayEnzyme InhibitorsGene Expression Regulation, NeoplasticHematologic NeoplasmsHeterocyclic Compounds, 4 or More RingsHistone AcetyltransferasesHumansMaleMiceMice, SCIDModels, MolecularNeoplasmsProstatic Neoplasms, Castration-ResistantProtein ConformationReceptors, AndrogenXenograft Model Antitumor Assaysp300-CBP Transcription Factors

MeSH Terms

Acetyl Coenzyme AAnimalsAntineoplastic AgentsBinding, CompetitiveEnzyme InhibitorsHeterocyclic Compounds, 4 or More RingsHumansMaleModels, MolecularNeoplasmsProtein ConformationReceptors, AndrogenGene Expression Regulation, NeoplasticMice, SCIDCrystallography, X-RayCell LineageHematologic NeoplasmsCatalytic DomainXenograft Model Antitumor AssaysCell Line, TumorCell Proliferationp300-CBP Transcription FactorsMiceHistone AcetyltransferasesBiocatalysisProstatic Neoplasms, Castration-Resistant

Keywords

Lineage (genetic)Computational biologyDrug discoveryChemistryBiologyGeneticsBioinformaticsGene

Sustainable Development Goals

SDG 0: Good health and well-being