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Perforin and granzymes: function, dysfunction and human pathology

Nature Reviews Immunology(2015)10.1038/nri3839Source: DataRank Database

Perforin and granzymes: function, dysfunction and human pathology is a research paper published in Nature Reviews Immunology (2015). On theSindex it has a DataRank of 10.5. It has been cited 1,304 times, with 200 citing works in its 1-hop citation network.

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10.5DataRank · unranked

Scored on demand from live citation data

1,304 citations · 200 citing works in its network

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Linked data & code

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Impact (FWCI 34.81)OA: closedTopics (34)Linked Datasets (25)DataCite Reuse (25)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (0/2)

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 10%Citation Network 90%

Base Score Contribution

1.1

From this paper's citation signal

Citation Network Contribution

9.4

From 200 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 200 citers.

Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration
Journal for ImmunoTherapy of Cancer201973 citations20 referencesContributes 0.215
The Degradome database: expanding roles of mammalian proteases in life and disease
Nucleic Acids Research201598 citations26 referencesContributes 0.177
Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns
Journal of Immunological Methods201784 citations27 referencesContributes 0.165
Mechanistic Projection of First‐in‐Human Dose for Bispecific Immunomodulatory P‐Cadherin LP‐DART: An Integrated PK/PD Modeling Approach
Clinical Pharmacology & Therapeutics201652 citations26 referencesContributes 0.153
Granzyme B PET Imaging as a Predictive Biomarker of Immunotherapy Response
Cancer Research2017325 citations39 referencesContributes 0.148

Authors (3)

James C. Whisstock,Joseph A. Trapani ORCID,Ilia Voskoboinik ORCID

Live enrichment

PubMed:25998963 OpenAlex:https://openalex.org/W1516464304

FWCI

34.81

Citation Percentile

1.0%

Citation Trend

2014

2015

2016

2017

2018

2019

2020

2021

2022

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2024

2025

2026

closedLicense: http://www.springer.com/tdm

publisherhttp://www.nature.com/articles/nri3839.pdf

publisherhttp://www.nature.com/articles/nri3839

journalhttps://doi.org/10.1038/nri3839

repositoryhttps://pubmed.ncbi.nlm.nih.gov/25998963

Fields of Study

Autoimmune and Inflammatory Disorders ResearchAcute Lymphoblastic Leukemia researchChildhood Cancer Survivors' Quality of Life

MeSH Terms

AnimalsCell CommunicationCytosolExocytosisHumansImmune System DiseasesInfectionsInflammationKiller Cells, NaturalNeoplasmsPolymorphism, GeneticEndosomesT-Lymphocytes, CytotoxicApoptosisSecretory VesiclesGranzymesPerforin

Keywords

PerforinGranzymeGranzyme BGranzyme ABiologyCell biologyCytotoxic T cellProteasesImmune systemImmunologyT cellCD8GeneticsBiochemistry

Sustainable Development Goals

SDG 0: Zero hunger

Additional file 6 of Prognostic Role of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

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Additional file 6 of Prognostic Role of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

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Additional file 5 of Prognostic Role of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

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Additional file 5 of Prognostic Role of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

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Additional file 4 of Prognostic Role of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

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Additional file 4 of Prognostic Role of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

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Additional file 3 of Prognostic Role of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

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Additional file 3 of Prognostic Role of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

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Additional file 2 of Prognostic Role of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

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Additional file 2 of Prognostic Role of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

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Additional file 1 of Prognostic Role of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

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Additional file 1 of Prognostic Role of Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

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Additional file 11 of Ileum tissue single-cell mRNA sequencing elucidates the cellular architecture of pathophysiological changes associated with weaning in piglets

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Additional file 11 of Ileum tissue single-cell mRNA sequencing elucidates the cellular architecture of pathophysiological changes associated with weaning in piglets

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Additional file 12 of Ileum tissue single-cell mRNA sequencing elucidates the cellular architecture of pathophysiological changes associated with weaning in piglets

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Additional file 12 of Ileum tissue single-cell mRNA sequencing elucidates the cellular architecture of pathophysiological changes associated with weaning in piglets

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Additional file 13 of Ileum tissue single-cell mRNA sequencing elucidates the cellular architecture of pathophysiological changes associated with weaning in piglets

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Additional file 13 of Ileum tissue single-cell mRNA sequencing elucidates the cellular architecture of pathophysiological changes associated with weaning in piglets

10.6084/m9.figshare.19930312figshare

Additional file 14 of Ileum tissue single-cell mRNA sequencing elucidates the cellular architecture of pathophysiological changes associated with weaning in piglets

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Additional file 14 of Ileum tissue single-cell mRNA sequencing elucidates the cellular architecture of pathophysiological changes associated with weaning in piglets

10.6084/m9.figshare.19930315figshare