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SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia

Leukemia(2020)10.1038/s41375-020-0845-6Source: DataRank Database

SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia is a research paper published in Leukemia (2020). On theSindex it has a DataRank of 0. It has been cited 128 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access128 citations

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (15 grants)Impact (FWCI 11.48)OA: greenTopics (73)IDs (PubMed, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Olga Lancho ORCID,Gregory S. Ducker ORCID,Jonathan M. Ghergurovich ORCID,Xincheng Xu ORCID,Victoria da Silva-Diz ORCID

Live enrichment

PubMed:32382081 OpenAlex:https://openalex.org/W3023443595

U.S. Department of Health & Human Services | National Institutes of Health

Grant: R00CA215307

U.S. Department of Health & Human Services | National Institutes of Health

Grant: R01CA236936

U.S. Department of Health & Human Services | National Institutes of Health

Grant: R00CA197869

U.S. Department of Health & Human Services | National Institutes of Health

Grant: 1DP1DK113643

U.S. Department of Health & Human Services | National Institutes of Health

Grant: R01CA163591

American Cancer Society

Grant: RSG-19-161-01-TBE

Rutgers Cancer Institute of New Jersey

Grant: P30CA072720

National Institutes of Health

Grant: 1R01CA236936-01A1

The role of glutaminolysis as a therapeutic target in T-ALL

National Institutes of Health

Grant: 2R01CA163591-06

Tumor Cell Dependence on Host Metabolism

European Commission

Grant: 751423

CD8+ T cell metabolism in anti-tumor response

National Institutes of Health

Grant: 5DP1DK113643-02

Metabolism in Action: Quantitative Fluxes in Mammals

National Institutes of Health

Grant: 5R00CA215307-05

Glycine metabolism in cancer

National Institutes of Health

Grant: 5R00CA197869-05

Functional dissection of oncogenic enhancers

National Institutes of Health

Grant: 3P30CA072720-07S2

CANCER CENTER SUPPORT GRANT

NIDDK NIH HHS

Grant: DP1 DK113643

FWCI

11.48

Citation Percentile

1.0%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

greenLicense: Springer TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7647950

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7647950

publisherhttp://www.nature.com/articles/s41375-020-0845-6.pdf

publisherhttp://www.nature.com/articles/s41375-020-0845-6

journalhttps://doi.org/10.1038/s41375-020-0845-6

Fields of Study

Acute Lymphoblastic Leukemia researchChildhood Cancer Survivors' Quality of LifeEpigenetics and DNA Methylation0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsAntimetabolites, AntineoplasticApoptosisCell ProliferationDrug SynergismGene Expression Regulation, LeukemicGlycine HydroxymethyltransferaseHumansMaleMethotrexateMiceMice, Inbred C57BLPrecursor T-Cell Lymphoblastic Leukemia-LymphomaTumor Cells, CulturedXenograft Model Antitumor Assays

MeSH Terms

AnimalsAntimetabolites, AntineoplasticDrug SynergismHumansMaleMethotrexateMice, Inbred C57BLGlycine HydroxymethyltransferaseTumor Cells, CulturedGene Expression Regulation, LeukemicApoptosisXenograft Model Antitumor AssaysCell ProliferationMicePrecursor T-Cell Lymphoblastic Leukemia-Lymphoma

Keywords

Serine hydroxymethyltransferaseMethotrexateIn vivoSerineDihydrofolate reductaseAntifolateBiologyLeukemiaCancer researchAcute lymphocytic leukemiaBiochemistryEnzymePharmacologyAntimetaboliteImmunologyLymphoblastic LeukemiaMaleAntimetabolites, AntineoplasticApoptosisfolatePrecursor T-Cell Lymphoblastic Leukemia-LymphomaArticleMiceTumor Cells, CulturedcancerAnimalsHumansCell ProliferationGlycine HydroxymethyltransferaseGene Expression Regulation, LeukemicAnimals; Antimetabolites, Antineoplastic; Apoptosis; Cell Proliferation; Glycine Hydroxymethyltransferase; Humans; Male; Methotrexate; Mice; Mice, Inbred C57BL; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; Drug Synergism; Gene Expression Regulation, Leukemicsmall molecule inhibitorDrug SynergismXenograft Model Antitumor AssaysMice, Inbred C57BLT-ALLSHMT

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being