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Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer’s disease

Translational Psychiatry(2021)10.1038/s41398-021-01263-4Source: DataRank Database

Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer’s disease is a research paper published in Translational Psychiatry (2021). On theSindex it has a DataRank of 0. It has been cited 42 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access42 citations

Cite:

Linked data & code

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (30 grants)Impact (FWCI 2.39)OA: goldTopics (54)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Yury Loika ORCID,Yongjin P. Park ORCID,David A. Bennett ORCID,Manolis Kellis ORCID,Alexander M. Kulminski ORCID

Live enrichment

PubMed:33637690 PMC:PMC7910483 OpenAlex:https://openalex.org/W3132378316

U.S. Department of Health & Human Services | National Institutes of Health

Grant: R01 AG15819

U.S. Department of Health & Human Services | National Institutes of Health

Grant: R01 AG17917

U.S. Department of Health & Human Services | National Institutes of Health

Grant: R01 AG36042

U.S. Department of Health & Human Services | National Institutes of Health

Grant: R01 AG61356

U.S. Department of Health & Human Services | National Institutes of Health

Grant: RF1 AG054012

U.S. Department of Health & Human Services | National Institutes of Health

Grant: R01 AG058002

U.S. Department of Health & Human Services | National Institutes of Health

Grant: R01 AG062335

U.S. Department of Health & Human Services | National Institutes of Health

Grant: RF1 AG062377

U.S. Department of Health & Human Services | National Institutes of Health

Grant: U01 NS110453

NIA NIH HHS

Grant: P30 AG010161

NIA NIH HHS

Grant: R01 AG047310

NIA NIH HHS

Grant: U01 AG061356

NIA NIH HHS

Grant: R01 AG015819

NIA NIH HHS

Grant: R01 AG017917

NIA NIH HHS

Grant: R01 AG061853

NIA NIH HHS

Grant: R01 AG036042

NIA NIH HHS

Grant: R01 AG070488

NIA NIH HHS

Grant: R01 AG065477

NIA NIH HHS

Grant: U54 AG052427

National Institutes of Health

Grant: 1RF1AG062377-01

Dissection of endosomal trafficking mechanisms in Alzheimer's Disease

National Institutes of Health

Grant: 5R01AG017917-20

Epidemiologic Study of Neural Reserve and Neurobiology of Aging

National Institutes of Health

Grant: 5R01AG047310-04

Life Course and Genetic and Non-genetic Factors in Health and Survival

National Institutes of Health

Grant: 5R01AG058002-05

Epigenomic, transcriptional and cellular dissection of Alzheimer's variants

National Institutes of Health

Grant: 1RF1AG054012-01

Cell type specific epigenetic analysis to understand complex mechanisms underlying Alzheimer's disease phenotypes

National Institutes of Health

Grant: 5R01AG062335-05

Elucidating the Molecular Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Disease

National Institutes of Health

Grant: 5R01AG036042-05

Exploring the Role of the Brain Epigenome: Cognitive Decline and Life Experiences

National Institutes of Health

Grant: 1P30AG010161-01

SHORT-TERM STABILITY OF CLINICAL TESTS

National Institutes of Health

Grant: 5R01AG061853-05

ApoE2 and protective molecular signatures in Alzheimer's disease and aging

National Institutes of Health

Grant: 1U01NS110453-01

Single-cell transcriptional and epigenomic dissection of Alzheimer's Disease and Related Dementias

National Institutes of Health

Grant: 5R01AG015819-07

Risk Factors, Pathology, and Clinical Expressions of AD

FWCI

2.39

Citation Percentile

0.9%

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://www.nature.com/articles/s41398-021-01263-4.pdf

publisherhttps://www.nature.com/articles/s41398-021-01263-4.pdf

publisherhttps://www.nature.com/articles/s41398-021-01263-4

journalhttps://doi.org/10.1038/s41398-021-01263-4

repositoryhttps://pubmed.ncbi.nlm.nih.gov/33637690

Fields of Study

Alzheimer's disease research and treatmentsEndoplasmic Reticulum Stress and DiseaseGenetic Associations and Epidemiology0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Exome SequencingAlzheimer DiseaseEndoribonucleasesHumansMembrane ProteinsAspartic Acid EndopeptidasesProtein Serine-Threonine KinasesGenetic Predisposition to DiseasePolymorphism, Single NucleotideApolipoprotein E4Genome-Wide Association StudyExome

Keywords

Genome-wide association studyAlzheimer's Disease Neuroimaging InitiativeMinor allele frequencyExomeMissense mutationBiologyExpression quantitative trait lociGenetic associationGeneticsAlleleExome sequencingPosterior cingulateApolipoprotein ESingle-nucleotide polymorphismAlzheimer's diseaseDiseaseGeneNeuroscienceAllele frequencyMedicinePhenotypeGenotypePathologyCortex (anatomy)Apolipoprotein E4Membrane ProteinsNeurosciences. Biological psychiatry. NeuropsychiatryProtein Serine-Threonine KinasesPolymorphism, Single NucleotideArticleAlzheimer DiseaseEndoribonucleasesAspartic Acid EndopeptidasesHumansGenetic Predisposition to DiseaseRC321-571

Sustainable Development Goals

SDG 0: Good health and well-being