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Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine

Nature Communications(2021)10.1038/s41467-021-21053-2Source: DataRank Database

Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine is a research paper published in Nature Communications (2021). On theSindex it has a DataRank of 0. It has been cited 65 times.

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Open Access65 citations

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ensembl omim refseq uniprot pdb doi

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Enrichment:Funding (11 grants)OA: goldTopics (66)IDs (PubMed, PMC)Annotations (6)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (24)

Martin D. Jennings ORCID,Siobhan Crilly ORCID,Sarah Legraie,Sarah E. Withers,Sara Cuvertino ORCID

Live enrichment

PubMed:33547280 PMC:PMC7864902

Biotechnology and Biological Sciences Research Council

Grant: BB/N014049/1

Specialised ribosomes facilitating cellular responses to oxidative stress

Stroke Association

Grant: TSALECT2017/02

Austrian Science Fund FWF

Grant: P 31727

Wellcome Trust

Grant: WT098051

Austrian Science Fund FWF

Grant: W 1226

Austrian Science Fund FWF

Grant: P 27893

Biotechnology and Biological Sciences Research Council

Grant: BB/S014667/1

National Institute for Health Research (NIHR)

Grant: IS-BRC-1215-20007

National Centre for the Replacement, Refinement and Reduction of Animals in Research

Grant: NC/N002598/1

Using zebrafish for pre-clinical brain haemorrhage research

Wellcome Trust

Grant: 098051

Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers

Wellcome Trust

goldLicense: cc-by

publisherhttps://www.nature.com/articles/s41467-021-21053-2.pdf

publisherhttps://www.nature.com/articles/s41467-021-21053-2

repositoryhttps://research.manchester.ac.uk/en/publications/d9e95576-9e14-4ca9-8720-4d502339c8cd

repositoryhttps://digitalcommons.wustl.edu/open_access_pubs/10136

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7864902

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

RibosomesEmbryo, NonmammalianAnimalsZebrafishHumansSaccharomyces cerevisiaeMicrognathismMicrocephalySpermidineLysinePeptidesRNA-Binding ProteinsZebrafish ProteinsSaccharomyces cerevisiae ProteinsProtein IsoformsPeptide Initiation FactorsSequence AlignmentDevelopmental DisabilitiesProtein BiosynthesisGene Expression Regulation, DevelopmentalAmino Acid SequenceProtein ConformationSequence Homology, Amino AcidAdolescentChildFemaleMaleEukaryotic Translation Initiation Factor 5A

Keywords

MalePolyamine570Embryo, NonmammalianAdolescentPromotes translationProtein ConformationScienceDevelopmental DisabilitiesMicrognathismIntellectual disability610ArticleHypusineIn-vivoPeptide Initiation FactorsComplexAnimalsHumansProtein IsoformsAmino Acid SequenceElongationChildLysineQGene Expression Regulation, DevelopmentalRNA-Binding ProteinsMessenger-rnaTranslation factor EIF5AProtein BiosynthesisMicrocephalyFemalePeptidesRibosomesMutations

Sustainable Development Goals

SDG 3: 3. Good health

Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine

FAIR Checklist

Authors (24)

Funding (11 grants)

Open Access

Topics

Annotations (Europe PMC)