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Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma restrict CD8+ T cell activation and limit responsiveness to immunotherapy in mice

Nature Communications(2024)10.1038/s41467-024-50441-7Source: DataRank Database

Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma restrict CD8+ T cell activation and limit responsiveness to immunotherapy in mice is a research paper published in Nature Communications (2024). On theSindex it has a DataRank of 1.4. It has been cited 80 times, with 78 citing works in its 1-hop citation network.

N/A

1.4DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access80 citations · 78 citing works in its network

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Linked data & code

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Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE235246

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (11 grants)Impact (FWCI 13.32)OA: goldTopics (85)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 46%Citation Network 54%

Base Score Contribution

0.659

From this paper's citation signal

Citation Network Contribution

0.774

From 48 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 78 citers.

Resveratrol and pancreatic cancers: Questions and future perspectives
World Journal of Gastrointestinal Oncology20254 citations24 referencesContributes 0.067
Stimuli-responsive polymer-dasatinib prodrug to reprogram cancer-associated fibroblasts for boosted immunotherapy
Journal of Controlled Release202524 citations51 referencesContributes 0.063
Senescence-to-Pyroptosis Nanotuners: Navigating Tumor Inflammatory Microenvironment for Enhanced Immunotherapy
Nano Letters20255 citations40 referencesContributes 0.045
Cellular senescence in the cancer microenvironment
The Journal of Biochemistry20255 citations47 referencesContributes 0.038
Targeting OxLDL-mediated CD36 + CAF reprogramming potentiates PD-1 immunotherapy in osteosarcoma
Molecular Cancer20254 citations44 referencesContributes 0.037

Authors (22)

Rachel E. Kahn ORCID,Lutfi Hodali,Reba Condiotti,Yarden Engel,Ela Elyada

Live enrichment

PubMed:39039076 PMC:PMC11263607 OpenAlex:https://openalex.org/W4400887447

NCI NIH HHS

Grant: R01 CA217208

NCI NIH HHS

Grant: R01 CA276512

Israel Science Foundation (ISF)

Grant: 2621/18

NIA NIH HHS

Grant: R01 AG059244

NCI NIH HHS

Grant: R01 CA252225

NCI NIH HHS

Grant: R00 CA252153

National Institutes of Health

Grant: 7R01CA252225-03

Defining metabolic adaptations within the PDAC "arid" tumor microenvironment

National Institutes of Health

Grant: 5R01CA276512-02

Stromal and vascular inputs into pancreatic cancer tumor neighborhoods

National Institutes of Health

Grant: 1R01CA217208-01A1

SENESCENT STROMA STIMULATES INFLAMMATION TO PROMOTE TUMORIGENESIS

National Institutes of Health

Grant: 5R01AG059244-05

MICROENVIRONMENTAL CONTROLS OF TUMOR DORMANCY

National Institutes of Health

Grant: 1K99CA252153-01A1

Dissecting the oncogenic and pro-metastatic roles of PTHLH-mediated calcium signaling in pancreatic cancer

FWCI

13.32

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

goldLicense: cc-by

journalhttps://www.nature.com/articles/s41467-024-50441-7.pdf

publisherhttps://www.nature.com/articles/s41467-024-50441-7.pdf

publisherhttps://www.nature.com/articles/s41467-024-50441-7

journalhttps://doi.org/10.1038/s41467-024-50441-7

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39039076

Fields of Study

Immune cells in cancerImmunotherapy and Immune ResponsesEpigenetics and DNA Methylation0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsCancer-Associated FibroblastsPancreatic NeoplasmsCD8-Positive T-LymphocytesMiceHumansCarcinoma, Pancreatic DuctalCellular SenescenceImmunotherapySulfonamidesMice, Inbred C57BLCell Line, TumorLymphocyte ActivationFemaleImmune Checkpoint InhibitorsAdenocarcinomaMaleBridged Bicyclo Compounds, Heterocyclic

MeSH Terms

Cancer-Associated FibroblastsImmune Checkpoint InhibitorsAdenocarcinomaAnimalsFemaleHumansImmunotherapyLymphocyte ActivationMaleMice, Inbred C57BLPancreatic NeoplasmsSulfonamidesCellular SenescenceCD8-Positive T-LymphocytesBridged Bicyclo Compounds, HeterocyclicCarcinoma, Pancreatic DuctalCell Line, TumorMice

Keywords

Cancer researchCytotoxic T cellImmunotherapyPancreatic cancerCD8StromaImmune systemBiologyCancerCancer-Associated FibroblastsCancer immunotherapyAdenocarcinomaTumor microenvironmentImmunologyImmunohistochemistryMaleScience610CD8-Positive T-LymphocytesInbred C57BLLymphocyte ActivationArticleCell LineBridged Bicyclo CompoundsMiceCell Line, TumorMedicine and Health SciencesAnimalsHumansImmune Checkpoint InhibitorsCellular SenescenceSulfonamidesTumorCarcinomaHeterocyclicQICTS (Institute of Clinical and Translational Sciences)Bridged Bicyclo Compounds, HeterocyclicPancreatic NeoplasmsMice, Inbred C57BLPancreatic DuctalFemaleCarcinoma, Pancreatic Ductal

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being