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Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function

Nature Communications(2024)10.1038/s41467-024-54836-4Source: DataRank Database

Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function is a research paper published in Nature Communications (2024). On theSindex it has a DataRank of 0.461. It has been cited 16 times, with 11 citing works in its 1-hop citation network.

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0.461DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access16 citations · 11 citing works in its network

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Linked data & code

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Data availability

Repositories this paper deposited data in (declared in PubMed).

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (13 grants)Impact (FWCI 2.67)OA: goldTopics (55)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 92%Citation Network 8%

Base Score Contribution

0.425

From this paper's citation signal

Citation Network Contribution

0.0362

From 4 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 11 citers.

Signaling by latrophilin adhesion-GPCRs in synapse assembly
Neuroscience202511 citations112 referencesContributes 0.022
Self-cleavage of the GAIN domain of adhesion G protein-coupled receptors requires multiple domain-extrinsic factors
Nature Communications20251 citations55 referencesContributes 0.013
The expanding roles of adhesion GPCRs in neural circuit assembly
Molecules and Cells20261 citations140 referencesContributes 0.005
Synaptic Cell Adhesion: A Functional Perspective
Advances in neurobiology20261 citations248 referencesContributes 0.003
Mechanistic insights into adhesion GPCR autoproteolysis by a multiscale computational approach
Research Square20250 citations80 referencesContributes 0.000

Authors (9)

Kristína Cechová ORCID,Sumit J. Bandekar ORCID,Katherine Leon ORCID,Przemysław Dutka ORCID,Gracie Siffer ORCID

Live enrichment

PubMed:39627215 PMC:PMC11615224 OpenAlex:https://openalex.org/W4405021571

NIGMS NIH HHS

Grant: R01 GM140272

NIGMS NIH HHS

Grant: R01 GM117372

NIGMS NIH HHS

Grant: R01 GM134035

NIGMS NIH HHS

Grant: F32 GM142266

NIGMS NIH HHS

Grant: R35 GM148412

NIH HHS

Grant: S10 OD028655

NIGMS NIH HHS

Grant: T32 GM140995

National Institutes of Health

Grant: 5T32GM140995-05

Molecular Biophysics Training Program at Northwestern University

National Institutes of Health

Grant: 3R01GM134035-03S1

Structural and Functional Studies of Teneurins: A bacterial toxin homolog in human

National Institutes of Health

Grant: 3R35GM148412-03S1

Structural and Functional Studies of Cell-Adhesion Receptors

National Institutes of Health

Grant: 5R01GM140272-05

Quantitative analysis of metabotropic glutamate receptor activation and modulation

National Institutes of Health

Grant: 5R01GM117372-07

Chaperone-Assisted Structure Determination of Membrane Proteins

National Institutes of Health

Grant: 1F32GM142266-01

Structure, Function, and Antibody-based Modulation of GPR126: Regulation of an Adhesion GPCR by its Extracellular Region

FWCI

2.67

Citation Percentile

0.9%

Citation Trend

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://www.nature.com/articles/s41467-024-54836-4.pdf

publisherhttps://www.nature.com/articles/s41467-024-54836-4.pdf

publisherhttps://www.nature.com/articles/s41467-024-54836-4

journalhttps://doi.org/10.1038/s41467-024-54836-4

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39627215

Fields of Study

Receptor Mechanisms and SignalingMonoclonal and Polyclonal Antibodies ResearchMass Spectrometry Techniques and Applications0301 basic medicine03 medical and health sciences

MeSH Terms

Protein DomainsSingle Molecule ImagingAnimalsCell MembraneHumansModels, MolecularMutationProtein BindingProtein ConformationSignal TransductionCryoelectron MicroscopyFluorescence Resonance Energy TransferReceptors, G-Protein-CoupledHEK293 Cells

Keywords

Förster resonance energy transferTransmembrane domainG protein-coupled receptorTransmembrane proteinBiophysicsCell biologyChemistryReceptorSingle-molecule FRETExtracellularCoupling (piping)Function (biology)Cell adhesion moleculeSignal transductionBiologyBiochemistryMaterials sciencePhysicsModels, Molecular570Protein ConformationScienceQCryoelectron MicroscopyCell Membrane610ArticleSingle Molecule ImagingReceptors, G-Protein-CoupledHEK293 CellsProtein DomainsMutationFluorescence Resonance Energy TransferHumansAnimalsProtein Binding